Clinicopathological characteristics of primary lung nuclear protein in testis carcinoma: A single‐institute experience of 10 cases
Abstract Background Nuclear protein in testis (NUT) carcinoma is a rare tumor associated with NUT rearrangement that can present as poorly differentiated to undifferentiated carcinoma, with or without abrupt squamous differentiation. It is often misdiagnosed as poorly differentiated carcinoma or und...
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doaj-458ee983e7724a449d85e0612f4c923d2020-11-25T04:07:15ZengWileyThoracic Cancer1759-77061759-77142020-11-0111113205321210.1111/1759-7714.13648Clinicopathological characteristics of primary lung nuclear protein in testis carcinoma: A single‐institute experience of 10 casesYoon Ah Cho0Yoon‐La Choi1Inwoo Hwang2Kyungjong Lee3Jong Ho Cho4Joungho Han5Department of Pathology and Translational Genomics Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Republic of KoreaDepartment of Pathology and Translational Genomics Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Republic of KoreaDepartment of Pathology and Translational Genomics Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Republic of KoreaRespiratory and Critical Care Division of Department of Internal Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine (SKKU‐SOM) Seoul South KoreaDepartment of Thoracic and Cardiovascular Surgery Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Republic of KoreaDepartment of Pathology and Translational Genomics Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Republic of KoreaAbstract Background Nuclear protein in testis (NUT) carcinoma is a rare tumor associated with NUT rearrangement that can present as poorly differentiated to undifferentiated carcinoma, with or without abrupt squamous differentiation. It is often misdiagnosed as poorly differentiated carcinoma or undifferentiated carcinoma if NUT is not suspected. In this study, we retrospectively analyzed pulmonary NUT carcinoma cases diagnosed with NUT immunohistochemical staining and discuss the differential diagnosis to provide information for this rare and aggressive entity. Methods Cases, diagnosed as “NUT carcinoma” in lung pleura and “metastatic NUT carcinoma from the lung” in lymph nodes were diagnosed between 2017 and 2019 at the Samsung Medical Center (SMC). Clinical features such as age, sex, treatment and follow‐up period, and pathological reports were obtained by reviewing patients’ electronic medical records. Results A total of 10 NUT carcinoma cases were found in the SMC pathology database. Seven patients were men and six were non‐smokers. Tumor cells showed various cellular features such as round, squamoid, and spindle. Some cases had initially been misdiagnosed as spindle cell neoplasm, round cell sarcoma, squamous cell carcinoma and small cell carcinoma. All cases showed diffuse strong nuclear expression of NUT immunohistochemical staining, and some were positive for p63 staining and negative for CD56 staining. Conclusions NUT carcinoma is often misdiagnosed because of its various morphologies. It is important to consider NUT as one of the differential diagnoses when encountering lung biopsy with undifferentiated morphology. Key points Due to various morphological features, NUT carcinoma can be misdiagnosed It is important to consider NUT carcinoma when diagnosing a poorly differentiated or undifferentiated tumorhttps://doi.org/10.1111/1759-7714.13648Lung cancerNUT carcinomapathology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoon Ah Cho Yoon‐La Choi Inwoo Hwang Kyungjong Lee Jong Ho Cho Joungho Han |
spellingShingle |
Yoon Ah Cho Yoon‐La Choi Inwoo Hwang Kyungjong Lee Jong Ho Cho Joungho Han Clinicopathological characteristics of primary lung nuclear protein in testis carcinoma: A single‐institute experience of 10 cases Thoracic Cancer Lung cancer NUT carcinoma pathology |
author_facet |
Yoon Ah Cho Yoon‐La Choi Inwoo Hwang Kyungjong Lee Jong Ho Cho Joungho Han |
author_sort |
Yoon Ah Cho |
title |
Clinicopathological characteristics of primary lung nuclear protein in testis carcinoma: A single‐institute experience of 10 cases |
title_short |
Clinicopathological characteristics of primary lung nuclear protein in testis carcinoma: A single‐institute experience of 10 cases |
title_full |
Clinicopathological characteristics of primary lung nuclear protein in testis carcinoma: A single‐institute experience of 10 cases |
title_fullStr |
Clinicopathological characteristics of primary lung nuclear protein in testis carcinoma: A single‐institute experience of 10 cases |
title_full_unstemmed |
Clinicopathological characteristics of primary lung nuclear protein in testis carcinoma: A single‐institute experience of 10 cases |
title_sort |
clinicopathological characteristics of primary lung nuclear protein in testis carcinoma: a single‐institute experience of 10 cases |
publisher |
Wiley |
series |
Thoracic Cancer |
issn |
1759-7706 1759-7714 |
publishDate |
2020-11-01 |
description |
Abstract Background Nuclear protein in testis (NUT) carcinoma is a rare tumor associated with NUT rearrangement that can present as poorly differentiated to undifferentiated carcinoma, with or without abrupt squamous differentiation. It is often misdiagnosed as poorly differentiated carcinoma or undifferentiated carcinoma if NUT is not suspected. In this study, we retrospectively analyzed pulmonary NUT carcinoma cases diagnosed with NUT immunohistochemical staining and discuss the differential diagnosis to provide information for this rare and aggressive entity. Methods Cases, diagnosed as “NUT carcinoma” in lung pleura and “metastatic NUT carcinoma from the lung” in lymph nodes were diagnosed between 2017 and 2019 at the Samsung Medical Center (SMC). Clinical features such as age, sex, treatment and follow‐up period, and pathological reports were obtained by reviewing patients’ electronic medical records. Results A total of 10 NUT carcinoma cases were found in the SMC pathology database. Seven patients were men and six were non‐smokers. Tumor cells showed various cellular features such as round, squamoid, and spindle. Some cases had initially been misdiagnosed as spindle cell neoplasm, round cell sarcoma, squamous cell carcinoma and small cell carcinoma. All cases showed diffuse strong nuclear expression of NUT immunohistochemical staining, and some were positive for p63 staining and negative for CD56 staining. Conclusions NUT carcinoma is often misdiagnosed because of its various morphologies. It is important to consider NUT as one of the differential diagnoses when encountering lung biopsy with undifferentiated morphology. Key points Due to various morphological features, NUT carcinoma can be misdiagnosed It is important to consider NUT carcinoma when diagnosing a poorly differentiated or undifferentiated tumor |
topic |
Lung cancer NUT carcinoma pathology |
url |
https://doi.org/10.1111/1759-7714.13648 |
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