Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review
Cytidine 5’-diphosphocholine has been widely studied in systemic neurodegenerative diseases, like Alzheimer’s disease, Parkinson’s disease, and brain ischemia. The rationale for the use of citicoline in ophthalmological neurodegenerative diseases, including glaucoma, anterior ischemic optic neuropat...
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doaj-4596f91e4ec24731b625272701a982a02021-03-21T00:01:31ZengMDPI AGPharmaceuticals1424-82472021-03-011428128110.3390/ph14030281Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive ReviewFrancesco Oddone0Luca Rossetti1Mariacristina Parravano2Diego Sbardella3Massimo Coletta4Lucia Ziccardi5Gloria Roberti6Carmela Carnevale7Dario Romano8Gianluca Manni9Vincenzo Parisi10IRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, ItalyEye Clinic, ASST Santi Paolo e Carlo, San Paolo Hospital, University of Milan, Via Antonio di Rudinì, 8, 20142 Milan, ItalyIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, ItalyIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, ItalyDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, ItalyIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, ItalyIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, ItalyIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, ItalyEye Clinic, ASST Santi Paolo e Carlo, San Paolo Hospital, University of Milan, Via Antonio di Rudinì, 8, 20142 Milan, ItalyDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, ItalyIRCCS-Fondazione Bietti, Rome, Via Livenza, 3, 00198 Rome, ItalyCytidine 5’-diphosphocholine has been widely studied in systemic neurodegenerative diseases, like Alzheimer’s disease, Parkinson’s disease, and brain ischemia. The rationale for the use of citicoline in ophthalmological neurodegenerative diseases, including glaucoma, anterior ischemic optic neuropathy, and diabetic retinopathy, is founded on its multifactorial mechanism of action and the involvement in several metabolic pathways, including phospholipid homeostasis, mitochondrial dynamics, as well as cholinergic and dopaminergic transmission, all being involved in the complexity of the visual transmission. This narrative review is aimed at reporting both pre-clinical data regarding the involvement of citicoline in such metabolic pathways <b>(</b>including new insights about its role in the intracellular proteostasis through an interaction with the proteasome<b>)</b> and its effects on clinical psychophysical, electrophysiological, and morphological outcomes following its use in ophthalmological neurodegenerative diseases (including the results of the most recent prospective randomized clinical trials).https://www.mdpi.com/1424-8247/14/3/281retinal ganglion cellsciticolineapoptosisproteasomeneuroprotectionneurodegeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesco Oddone Luca Rossetti Mariacristina Parravano Diego Sbardella Massimo Coletta Lucia Ziccardi Gloria Roberti Carmela Carnevale Dario Romano Gianluca Manni Vincenzo Parisi |
spellingShingle |
Francesco Oddone Luca Rossetti Mariacristina Parravano Diego Sbardella Massimo Coletta Lucia Ziccardi Gloria Roberti Carmela Carnevale Dario Romano Gianluca Manni Vincenzo Parisi Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review Pharmaceuticals retinal ganglion cells citicoline apoptosis proteasome neuroprotection neurodegeneration |
author_facet |
Francesco Oddone Luca Rossetti Mariacristina Parravano Diego Sbardella Massimo Coletta Lucia Ziccardi Gloria Roberti Carmela Carnevale Dario Romano Gianluca Manni Vincenzo Parisi |
author_sort |
Francesco Oddone |
title |
Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review |
title_short |
Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review |
title_full |
Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review |
title_fullStr |
Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review |
title_full_unstemmed |
Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review |
title_sort |
citicoline in ophthalmological neurodegenerative disease: a comprehensive review |
publisher |
MDPI AG |
series |
Pharmaceuticals |
issn |
1424-8247 |
publishDate |
2021-03-01 |
description |
Cytidine 5’-diphosphocholine has been widely studied in systemic neurodegenerative diseases, like Alzheimer’s disease, Parkinson’s disease, and brain ischemia. The rationale for the use of citicoline in ophthalmological neurodegenerative diseases, including glaucoma, anterior ischemic optic neuropathy, and diabetic retinopathy, is founded on its multifactorial mechanism of action and the involvement in several metabolic pathways, including phospholipid homeostasis, mitochondrial dynamics, as well as cholinergic and dopaminergic transmission, all being involved in the complexity of the visual transmission. This narrative review is aimed at reporting both pre-clinical data regarding the involvement of citicoline in such metabolic pathways <b>(</b>including new insights about its role in the intracellular proteostasis through an interaction with the proteasome<b>)</b> and its effects on clinical psychophysical, electrophysiological, and morphological outcomes following its use in ophthalmological neurodegenerative diseases (including the results of the most recent prospective randomized clinical trials). |
topic |
retinal ganglion cells citicoline apoptosis proteasome neuroprotection neurodegeneration |
url |
https://www.mdpi.com/1424-8247/14/3/281 |
work_keys_str_mv |
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