Arcanobacterium pyogenes: Virulence factors, importance in mastitis etiology and therapeutic (im)possibilities
Arcanobacterium pyogenes is an opportunistic pathogen, a causative agent of suppurative infections of organs and tissues in economically important livestock species. Most frequently this bacteria is isolated from inflamed lung lesions in pigs and cattle, in samples of uterine mucus of cows...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | srp |
| Published: |
Faculty of Veterinary Medicine, Belgrade
2011-01-01
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| Series: | Veterinarski Glasnik |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0350-2457/2011/0350-24571104235M.pdf |
| Summary: | Arcanobacterium pyogenes is an opportunistic pathogen, a causative agent of
suppurative infections of organs and tissues in economically important
livestock species. Most frequently this bacteria is isolated from inflamed
lung lesions in pigs and cattle, in samples of uterine mucus of cows with
endometritis and milk from cows with clinical mastitis. A. pyogenes possesses
a number of virulence factors: cholesterol-dependent cytolysin (pyolysin),
two neuraminidases, several proteases, extracellular matrix-binding proteins,
DNases, fimbriae. The virulence factors are well studied in laboratory
conditions, but the role of these factors in the pathogenesis of A. pyogenes
infections remains to be elucidated. Lately, the ability of A. pyogenes to
form biofilm in vivo has also been implicated as a virulence factor and a
possible cause of therapeutic failure. Despite the fact that A. pyogenes milk
isolates in cows with mastitis in vitro are very sensitive to β-lactam drugs
and tetracycline, experience has shown that therapy is usually ineffective,
prognosis is poor and the affected quarter is lost for milk production. |
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| ISSN: | 0350-2457 2406-0771 |