Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern China
Numerous animal studies have shown that high arsenic exposure can induce neural tube defect (NTD) formation. However, epidemiological evidence related to this finding is scarce. The key objective of our study is to evaluate whether maternal arsenic exposure is associated with NTD risk in Northern Ch...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-05-01
|
Series: | Environment International |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018325960 |
id |
doaj-45a075ff67f049fca15e69a7579ae33f |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bin Wang Yibing Zhu Lailai Yan Jingxu Zhang Xilong Wang Hefa Cheng Zhiwen Li Rongwei Ye Aiguo Ren |
spellingShingle |
Bin Wang Yibing Zhu Lailai Yan Jingxu Zhang Xilong Wang Hefa Cheng Zhiwen Li Rongwei Ye Aiguo Ren Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern China Environment International |
author_facet |
Bin Wang Yibing Zhu Lailai Yan Jingxu Zhang Xilong Wang Hefa Cheng Zhiwen Li Rongwei Ye Aiguo Ren |
author_sort |
Bin Wang |
title |
Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern China |
title_short |
Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern China |
title_full |
Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern China |
title_fullStr |
Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern China |
title_full_unstemmed |
Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern China |
title_sort |
association of maternal chronic arsenic exposure with the risk of neural tube defects in northern china |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2019-05-01 |
description |
Numerous animal studies have shown that high arsenic exposure can induce neural tube defect (NTD) formation. However, epidemiological evidence related to this finding is scarce. The key objective of our study is to evaluate whether maternal arsenic exposure is associated with NTD risk in Northern China. Our case–control study was conducted in 11 countries or cities in Shanxi and Hebei provinces during 2003–2007. A total of 774 mothers were included as participants: 511 controls and 263 cases (including 123 with anencephaly, 115 with spina bifida, 18 with encephalocele, and 7 with other NTD subtypes). The arsenic concentration was measured in a specific section of hair that grew from 3 months before to 3 months after conception. We found a higher hair arsenic concentration in the NTD cases with median (inter-quartile range) of 0.093 (0.025–0.387) μg/g hair than that in the controls with a value of 0.082 (0.030–0.414) μg/g hair. Maternal hair arsenic concentration above its median of the controls was associated with an increased risk of the total NTDs with an adjusted odds ratio (OR) of 1.32 [95% confidence interval (CI): (0.91–1.92)], which was not statistically significant (p = 0.14), although the crude OR without adjusting for the confounders of 1.68 (95% CI: 1.24–2.27; p < 0.001) suggested that hair arsenic is a risk factor of NTDs. There was no dose-response relationship between maternal hair arsenic concentration and the risk of total NTDs. Similar phenomena were found for anencephaly and spina bifida, respectively. Overall, our findings showed that maternal periconceptional arsenic exposure may not significantly contribute to the risk of NTD development in Northern China; other risk factors need to be further examined in future studies. Keywords: Neural tube defects, Risk, Arsenic, Hair, Northern China |
url |
http://www.sciencedirect.com/science/article/pii/S0160412018325960 |
work_keys_str_mv |
AT binwang associationofmaternalchronicarsenicexposurewiththeriskofneuraltubedefectsinnorthernchina AT yibingzhu associationofmaternalchronicarsenicexposurewiththeriskofneuraltubedefectsinnorthernchina AT lailaiyan associationofmaternalchronicarsenicexposurewiththeriskofneuraltubedefectsinnorthernchina AT jingxuzhang associationofmaternalchronicarsenicexposurewiththeriskofneuraltubedefectsinnorthernchina AT xilongwang associationofmaternalchronicarsenicexposurewiththeriskofneuraltubedefectsinnorthernchina AT hefacheng associationofmaternalchronicarsenicexposurewiththeriskofneuraltubedefectsinnorthernchina AT zhiwenli associationofmaternalchronicarsenicexposurewiththeriskofneuraltubedefectsinnorthernchina AT rongweiye associationofmaternalchronicarsenicexposurewiththeriskofneuraltubedefectsinnorthernchina AT aiguoren associationofmaternalchronicarsenicexposurewiththeriskofneuraltubedefectsinnorthernchina |
_version_ |
1724767847972864000 |
spelling |
doaj-45a075ff67f049fca15e69a7579ae33f2020-11-25T02:44:03ZengElsevierEnvironment International0160-41202019-05-01126222227Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern ChinaBin Wang0Yibing Zhu1Lailai Yan2Jingxu Zhang3Xilong Wang4Hefa Cheng5Zhiwen Li6Rongwei Ye7Aiguo Ren8Institute of Reproductive and Child Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, PR China; Corresponding authors at: Peking University Health Science Center, No. 38, Xueyuan Road, Haidian District, Beijing City 100191, PR China.Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350005, PR ChinaDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing 100191, PR ChinaDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, PR ChinaInstitute of Reproductive and Child Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, PR China; College of Urban and Environmental Sciences, Peking University, 100871, PR ChinaCollege of Urban and Environmental Sciences, Peking University, 100871, PR ChinaInstitute of Reproductive and Child Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, PR China; Corresponding authors at: Peking University Health Science Center, No. 38, Xueyuan Road, Haidian District, Beijing City 100191, PR China.Institute of Reproductive and Child Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, PR ChinaInstitute of Reproductive and Child Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing 100191, PR ChinaNumerous animal studies have shown that high arsenic exposure can induce neural tube defect (NTD) formation. However, epidemiological evidence related to this finding is scarce. The key objective of our study is to evaluate whether maternal arsenic exposure is associated with NTD risk in Northern China. Our case–control study was conducted in 11 countries or cities in Shanxi and Hebei provinces during 2003–2007. A total of 774 mothers were included as participants: 511 controls and 263 cases (including 123 with anencephaly, 115 with spina bifida, 18 with encephalocele, and 7 with other NTD subtypes). The arsenic concentration was measured in a specific section of hair that grew from 3 months before to 3 months after conception. We found a higher hair arsenic concentration in the NTD cases with median (inter-quartile range) of 0.093 (0.025–0.387) μg/g hair than that in the controls with a value of 0.082 (0.030–0.414) μg/g hair. Maternal hair arsenic concentration above its median of the controls was associated with an increased risk of the total NTDs with an adjusted odds ratio (OR) of 1.32 [95% confidence interval (CI): (0.91–1.92)], which was not statistically significant (p = 0.14), although the crude OR without adjusting for the confounders of 1.68 (95% CI: 1.24–2.27; p < 0.001) suggested that hair arsenic is a risk factor of NTDs. There was no dose-response relationship between maternal hair arsenic concentration and the risk of total NTDs. Similar phenomena were found for anencephaly and spina bifida, respectively. Overall, our findings showed that maternal periconceptional arsenic exposure may not significantly contribute to the risk of NTD development in Northern China; other risk factors need to be further examined in future studies. Keywords: Neural tube defects, Risk, Arsenic, Hair, Northern Chinahttp://www.sciencedirect.com/science/article/pii/S0160412018325960 |