Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective study
Abstract Background Upper urinary tract infection (UTI) or pyelonephritis may increase the pathogenesis rate and risk of severe complications in children due to kidney atrophy. Objective A set of clinical symptoms, laboratory markers, and ultrasound findings were assessed to achieve the early diagno...
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doaj-45a720b18d9a450d864966878bfd278a2021-02-21T12:08:00ZengBMCBMC Infectious Diseases1471-23342021-02-012111910.1186/s12879-021-05887-1Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective studyDaryoosh Fahimi0Leila Khedmat1Azadeh Afshin2Zahra Noparast3Maryam Jafaripor4Effat Hosseinali Beigi5Maryam Ghodsi6Anahita Izadi7Sayed Yousef Mojtahedi8Children’s Hospital Medical Centre, Tehran University of Medical SciencesHealth Management Research Center, Baqiyatallah University of Medical SciencesDepartment of Pediatric Nephrology, Bahrami Hospital, Tehran University of Medical SciencesDepartment of Pediatric Nephrology, Bahrami Hospital, Tehran University of Medical SciencesFaculty of Medicine, Tehran University of Medical SciencesDepartment of Pediatric Intensive Care Unit, Bahrami Children’s Hospital, Tehran University of Medical SciencesDepartment of Pediatric Intensive Care Unit, Bahrami Children’s Hospital, Tehran University of Medical SciencesDepartment of Pediatric Infection Disease, Tehran University of Medical SciencesDepartment of Pediatric Nephrology, Bahrami Hospital, Tehran University of Medical SciencesAbstract Background Upper urinary tract infection (UTI) or pyelonephritis may increase the pathogenesis rate and risk of severe complications in children due to kidney atrophy. Objective A set of clinical symptoms, laboratory markers, and ultrasound findings were assessed to achieve the early diagnosis and prognosis of pyelonephritis in hospitalized pediatrics. Methods A cross-sectional study with 104 Iranian children (95 girls and 9 boys) aged 1 month to 12 years with acute pyelonephritis during 2012–2018 was conducted. The ultrasound examination of kidneys and urinary tract during hospitalization, the incidence of clinical symptoms, and laboratory markers in blood and urine were monitored to identify the best predictive factors of early diagnosis of this bacterial infection. Results Three-fourth of the patients had one of the four clinical symptoms of abdominal pain, constipation, dysuria, and vomiting, while others were asymptomatic. A much frequency of pyuria (88.46%), Escherichia coli in urine (92.31%), leukocytosis (81.73%), and high ESR (> 10 mm/h, 92.30%) and CRP (> 10 mg/L, 82.82%) was observed. The kidney and urinary tract ultrasonography only in 32.7% of children revealed findings in favor of pyelonephritis (cystitis, ureteral stones, and hydronephrosis). Conclusion There was a high frequency of clinical signs and laboratory markers associated with pyelonephritis. Ultrasound alone was not an efficient tool to track febrile UTI as most patients presented normal sonography.https://doi.org/10.1186/s12879-021-05887-1Acute pyelonephritisUrinary tract infectionRenal pathologyClinical signsUltrasoundPediatric |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daryoosh Fahimi Leila Khedmat Azadeh Afshin Zahra Noparast Maryam Jafaripor Effat Hosseinali Beigi Maryam Ghodsi Anahita Izadi Sayed Yousef Mojtahedi |
spellingShingle |
Daryoosh Fahimi Leila Khedmat Azadeh Afshin Zahra Noparast Maryam Jafaripor Effat Hosseinali Beigi Maryam Ghodsi Anahita Izadi Sayed Yousef Mojtahedi Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective study BMC Infectious Diseases Acute pyelonephritis Urinary tract infection Renal pathology Clinical signs Ultrasound Pediatric |
author_facet |
Daryoosh Fahimi Leila Khedmat Azadeh Afshin Zahra Noparast Maryam Jafaripor Effat Hosseinali Beigi Maryam Ghodsi Anahita Izadi Sayed Yousef Mojtahedi |
author_sort |
Daryoosh Fahimi |
title |
Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective study |
title_short |
Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective study |
title_full |
Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective study |
title_fullStr |
Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective study |
title_full_unstemmed |
Clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old Iranian children with pyelonephritis: a six-year cross-sectional retrospective study |
title_sort |
clinical manifestations, laboratory markers, and renal ultrasonographic examinations in 1-month to 12-year-old iranian children with pyelonephritis: a six-year cross-sectional retrospective study |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2021-02-01 |
description |
Abstract Background Upper urinary tract infection (UTI) or pyelonephritis may increase the pathogenesis rate and risk of severe complications in children due to kidney atrophy. Objective A set of clinical symptoms, laboratory markers, and ultrasound findings were assessed to achieve the early diagnosis and prognosis of pyelonephritis in hospitalized pediatrics. Methods A cross-sectional study with 104 Iranian children (95 girls and 9 boys) aged 1 month to 12 years with acute pyelonephritis during 2012–2018 was conducted. The ultrasound examination of kidneys and urinary tract during hospitalization, the incidence of clinical symptoms, and laboratory markers in blood and urine were monitored to identify the best predictive factors of early diagnosis of this bacterial infection. Results Three-fourth of the patients had one of the four clinical symptoms of abdominal pain, constipation, dysuria, and vomiting, while others were asymptomatic. A much frequency of pyuria (88.46%), Escherichia coli in urine (92.31%), leukocytosis (81.73%), and high ESR (> 10 mm/h, 92.30%) and CRP (> 10 mg/L, 82.82%) was observed. The kidney and urinary tract ultrasonography only in 32.7% of children revealed findings in favor of pyelonephritis (cystitis, ureteral stones, and hydronephrosis). Conclusion There was a high frequency of clinical signs and laboratory markers associated with pyelonephritis. Ultrasound alone was not an efficient tool to track febrile UTI as most patients presented normal sonography. |
topic |
Acute pyelonephritis Urinary tract infection Renal pathology Clinical signs Ultrasound Pediatric |
url |
https://doi.org/10.1186/s12879-021-05887-1 |
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