Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias

Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias

We have previously described gene expression changes during spontaneous immortalization of T-cells, thereby identifying cellular processes important for cell growth crisis escape and unlimited proliferation. Here, we analyze the same model to investigate the role of genome-wide methylation in the i...

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Bibliographic Details
Main Authors: Sofie Degerman, Mattias Landfors, Jan Konrad Siwicki, John Revie, Magnus Borssén, Emma Evelönn, Erik Forestier, Krystyna H. Chrzanowska, Patrik Rydén, W. Nicol Keith, Göran Roos
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558614000803

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