Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases
The amygdala is an almond-shaped nucleus located deep and medially within the temporal lobe and is thought to play a crucial role in the regulation of emotional processes. GABAergic neurotransmission inhibits the amygdala and prevents us from generating inappropriate emotional and behavioral respons...
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doaj-45ada5cbe255491db00a6a29d854f10c2020-11-24T23:39:40ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-08-011210.3389/fnins.2018.00562358571Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric DiseasesFan Jie0Guanghao Yin1Wei Yang2Modi Yang3Shuohui Gao4Jiayin Lv5Bingjin Li6Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaDepartment of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, ChinaThe amygdala is an almond-shaped nucleus located deep and medially within the temporal lobe and is thought to play a crucial role in the regulation of emotional processes. GABAergic neurotransmission inhibits the amygdala and prevents us from generating inappropriate emotional and behavioral responses. Stress may cause the reduction of the GABAergic interneuronal network and the development of neuropsychological diseases. In this review, we summarize the recent evidence investigating the possible mechanisms underlying GABAergic control of the amygdala and its interaction with acute and chronic stress. Taken together, this study may contribute to future progress in finding new approaches to reverse the attenuation of GABAergic neurotransmission induced by stress in the amygdala.https://www.frontiersin.org/article/10.3389/fnins.2018.00562/fullamygdalaGABAergicchronic stressacute stressanxiety |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fan Jie Guanghao Yin Wei Yang Modi Yang Shuohui Gao Jiayin Lv Bingjin Li |
spellingShingle |
Fan Jie Guanghao Yin Wei Yang Modi Yang Shuohui Gao Jiayin Lv Bingjin Li Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases Frontiers in Neuroscience amygdala GABAergic chronic stress acute stress anxiety |
author_facet |
Fan Jie Guanghao Yin Wei Yang Modi Yang Shuohui Gao Jiayin Lv Bingjin Li |
author_sort |
Fan Jie |
title |
Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases |
title_short |
Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases |
title_full |
Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases |
title_fullStr |
Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases |
title_full_unstemmed |
Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases |
title_sort |
stress in regulation of gaba amygdala system and relevance to neuropsychiatric diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2018-08-01 |
description |
The amygdala is an almond-shaped nucleus located deep and medially within the temporal lobe and is thought to play a crucial role in the regulation of emotional processes. GABAergic neurotransmission inhibits the amygdala and prevents us from generating inappropriate emotional and behavioral responses. Stress may cause the reduction of the GABAergic interneuronal network and the development of neuropsychological diseases. In this review, we summarize the recent evidence investigating the possible mechanisms underlying GABAergic control of the amygdala and its interaction with acute and chronic stress. Taken together, this study may contribute to future progress in finding new approaches to reverse the attenuation of GABAergic neurotransmission induced by stress in the amygdala. |
topic |
amygdala GABAergic chronic stress acute stress anxiety |
url |
https://www.frontiersin.org/article/10.3389/fnins.2018.00562/full |
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