Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming

Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming

The core pluripotency transcription factor NANOG is critical for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Although NANOG is phosphorylated at multiple residues, the role of NANOG phosphorylation in ESC self-renewal is incompletely understood, and no information exists r...

Full description

Bibliographic Details
Main Authors: Arven Saunders, Dan Li, Francesco Faiola, Xin Huang, Miguel Fidalgo, Diana Guallar, Junjun Ding, Fan Yang, Yang Xu, Hongwei Zhou, Jianlong Wang
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Stem Cell Reports
Subjects:
post-translational modification
self-renewal
iPSC
phospho-NANOG
serine to alanine mutation
pluripotency
reprogramming
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117301297

Internet

http://www.sciencedirect.com/science/article/pii/S2213671117301297

Similar Items