Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes?
ObjectiveCirculating biomarkers are useful in detection and monitoring of cardiovascular diseases. However, their role in aortic valve disease is unclear. Mechanisms are rapidly elucidated and sex differences are suggested to be involved. Therefore, we sought to identify biomarkers involved in aorti...
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doaj-45b210fd1a4a470b97f8f0c11eb67c9c2020-11-25T03:24:25ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-07-01810.3389/fcell.2020.00604538918Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes?Frederique E. C. M. Peeters0Elton A. M. P. Dudink1Bob Weijs2Larissa Fabritz3Winnie Chua4Bas L. J. H. Kietselaer5Joachim E. Wildberger6Steven J. R. Meex7Paulus Kirchhof8Harry J. G. M. Crijns9Leon J. Schurgers10Department of Cardiology and CARIM, Maastricht University Medical Center+, School for Cardiovascular Diseases, Maastricht, NetherlandsDepartment of Cardiology and CARIM, Maastricht University Medical Center+, School for Cardiovascular Diseases, Maastricht, NetherlandsDepartment of Cardiology and CARIM, Maastricht University Medical Center+, School for Cardiovascular Diseases, Maastricht, NetherlandsInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, United KingdomInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, United KingdomDepartment of Cardiology and CARIM, Maastricht University Medical Center+, School for Cardiovascular Diseases, Maastricht, NetherlandsDepartment of Radiology and Nuclear Medicine and CARIM, Maastricht University Medical Center+, School for Cardiovascular Diseases, Maastricht, NetherlandsDepartment of Clinical Chemistry and CARIM, Maastricht University Medical Center+, School for Cardiovascular Diseases, Maastricht, NetherlandsInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, United KingdomDepartment of Cardiology and CARIM, Maastricht University Medical Center+, School for Cardiovascular Diseases, Maastricht, NetherlandsDepartment of Biochemistry and CARIM, Maastricht University, School for Cardiovascular Diseases, Maastricht, NetherlandsObjectiveCirculating biomarkers are useful in detection and monitoring of cardiovascular diseases. However, their role in aortic valve disease is unclear. Mechanisms are rapidly elucidated and sex differences are suggested to be involved. Therefore, we sought to identify biomarkers involved in aortic valve calcification (AVC) stratified by sex.MethodsBlood samples of 34 patients with AVC (without further overt cardiovascular disease, including absence of hemodynamic consequences of valvular calcification) were compared with 136 patients without AVC. AVC was determined using computed tomography calcium scoring. Circulating biomarkers were quantified using a novel antibody-based method (Olink Proseek Multiplex Cardiovascular Panel I) and 92 biomarkers were compared between patients with and without AVC.ResultsIn the overall population, Interleukin-1 Receptor Antagonist and pappalysin-1 were associated with increased and decreased odds of having AVC. These differences were driven by the male population [IL1RA: OR 2.79 (1.16–6.70), p = 0.022; PAPPA: OR 0.30 (0.11–0.84), p = 0.021]. Furthermore, TNF-related activation-induced cytokine (TRANCE) and fibroblast growth factor-23 were associated decreased odds of having AVC, and monocyte chemotactic protein-1 was associated with increased odds of having AVC [TRANCE: OR 0.32 (0.12–0.80), p = 0.015; FGF23: OR 0.41 (0.170–0.991), p = 0.048; MCP1: OR 2.64 (1.02–6.81), p = 0.045]. In contrast, galanin peptides and ST2 were associated with increased odds of having AVC in females [GAL: OR 12.38 (1.31–116.7), p = 0.028; ST2: OR13.64 (1.21–153.33), p = 0.034].ConclusionIn this exploratory study, we identified biomarkers involved in inflammation, fibrosis and calcification which may be associated with having AVC. Biomarkers involved in fibrosis may show higher expression in females, whilst biomarkers involved in inflammation and calcification could associate with AVC in males.https://www.frontiersin.org/article/10.3389/fcell.2020.00604/fullaortic valve calcificationbiomarkerssex-specificfibrosisinflammation |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Frederique E. C. M. Peeters Elton A. M. P. Dudink Bob Weijs Larissa Fabritz Winnie Chua Bas L. J. H. Kietselaer Joachim E. Wildberger Steven J. R. Meex Paulus Kirchhof Harry J. G. M. Crijns Leon J. Schurgers |
spellingShingle |
Frederique E. C. M. Peeters Elton A. M. P. Dudink Bob Weijs Larissa Fabritz Winnie Chua Bas L. J. H. Kietselaer Joachim E. Wildberger Steven J. R. Meex Paulus Kirchhof Harry J. G. M. Crijns Leon J. Schurgers Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes? Frontiers in Cell and Developmental Biology aortic valve calcification biomarkers sex-specific fibrosis inflammation |
author_facet |
Frederique E. C. M. Peeters Elton A. M. P. Dudink Bob Weijs Larissa Fabritz Winnie Chua Bas L. J. H. Kietselaer Joachim E. Wildberger Steven J. R. Meex Paulus Kirchhof Harry J. G. M. Crijns Leon J. Schurgers |
author_sort |
Frederique E. C. M. Peeters |
title |
Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes? |
title_short |
Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes? |
title_full |
Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes? |
title_fullStr |
Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes? |
title_full_unstemmed |
Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes? |
title_sort |
biomarkers associated with aortic valve calcification: should we focus on sex specific processes? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-07-01 |
description |
ObjectiveCirculating biomarkers are useful in detection and monitoring of cardiovascular diseases. However, their role in aortic valve disease is unclear. Mechanisms are rapidly elucidated and sex differences are suggested to be involved. Therefore, we sought to identify biomarkers involved in aortic valve calcification (AVC) stratified by sex.MethodsBlood samples of 34 patients with AVC (without further overt cardiovascular disease, including absence of hemodynamic consequences of valvular calcification) were compared with 136 patients without AVC. AVC was determined using computed tomography calcium scoring. Circulating biomarkers were quantified using a novel antibody-based method (Olink Proseek Multiplex Cardiovascular Panel I) and 92 biomarkers were compared between patients with and without AVC.ResultsIn the overall population, Interleukin-1 Receptor Antagonist and pappalysin-1 were associated with increased and decreased odds of having AVC. These differences were driven by the male population [IL1RA: OR 2.79 (1.16–6.70), p = 0.022; PAPPA: OR 0.30 (0.11–0.84), p = 0.021]. Furthermore, TNF-related activation-induced cytokine (TRANCE) and fibroblast growth factor-23 were associated decreased odds of having AVC, and monocyte chemotactic protein-1 was associated with increased odds of having AVC [TRANCE: OR 0.32 (0.12–0.80), p = 0.015; FGF23: OR 0.41 (0.170–0.991), p = 0.048; MCP1: OR 2.64 (1.02–6.81), p = 0.045]. In contrast, galanin peptides and ST2 were associated with increased odds of having AVC in females [GAL: OR 12.38 (1.31–116.7), p = 0.028; ST2: OR13.64 (1.21–153.33), p = 0.034].ConclusionIn this exploratory study, we identified biomarkers involved in inflammation, fibrosis and calcification which may be associated with having AVC. Biomarkers involved in fibrosis may show higher expression in females, whilst biomarkers involved in inflammation and calcification could associate with AVC in males. |
topic |
aortic valve calcification biomarkers sex-specific fibrosis inflammation |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00604/full |
work_keys_str_mv |
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