Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages

Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages

Macrophage-mediated inflammatory response has been implicated in the pathogenesis of obesity and insulin resistance. Brd4 has emerged as a key regulator in the innate immune response. However, the role of Brd4 in obesity-associated inflammation and insulin resistance remains uncharacterized. Here, w...

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Bibliographic Details
Main Authors: Xiangming Hu, Xingchen Dong, Guo Li, Yanheng Chen, Jinjing Chen, Xiaoxin He, Hao Sun, Dong-Hyun Kim, Jongsook Kim Kemper, Lin-Feng Chen
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-04-01
Series:JCI Insight
Subjects:
Metabolism
Online Access:https://doi.org/10.1172/jci.insight.143379

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