A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment

A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment

There is currently a strong interest in using high-throughput in-vitro ion-channel screening data to make predictions regarding the cardiac toxicity potential of a new compound in both animal and human studies. A recent FDA think tank encourages the use of biophysical mathematical models of cardiac...

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Bibliographic Details
Main Authors: Hitesh eMistry, Mark Richard Davies, Giovanni Y Di Veroli
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Pharmacology
Subjects:
mathematical model
cardiac toxicity
ion-channel pharmacology
predictive pharmacology
biostatistics.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00059/full

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