Deficiency of eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity

Deficiency of eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity

Eukaryotic translation initiation factor 4B (eIF4B) plays an important role in mRNA translation initiation, cell survival and proliferation in vitro. However, its function in vivo is poorly understood. Here, we identified that eIF4B knockout (KO) in mice led to embryonic lethality, and the embryos d...

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Bibliographic Details
Main Authors: Biao Chen, Yuhai Chen, Kul Raj Rai, Xuefei Wang, Shasha Liu, Yingying Li, Meng Xiao, Yun Ma, Guoqing Wang, Guijie Guo, Shile Huang, Ji-Long Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
eIF4B
mouse mortality
viral infection
inflammation
antiviral immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.723885/full

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