The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour

In humans, copy-number variants of the CYFIP1 gene have been associated with autism spectrum disorders and schizophrenia. Here, the authors characterize Cyfip1-heterozygous mice, revealing that they display deficits in brain white matter structure and functional connectivity along with abnormal beha...

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Main Authors:	Nuria Domínguez-Iturza, Adrian C. Lo, Disha Shah, Marcelo Armendáriz, Anna Vannelli, Valentina Mercaldo, Massimo Trusel, Ka Wan Li, Denise Gastaldo, Ana Rita Santos, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, Manuel Mameli, Annemie Van der Linden, August B. Smit, Tilmann Achsel, Claudia Bagni
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11203-y

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spelling	doaj-45ce8718dbe54af7bd35ef3ffe5acc3a2021-05-11T12:30:14ZengNature Publishing GroupNature Communications2041-17232019-08-0110111310.1038/s41467-019-11203-yThe autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviourNuria Domínguez-Iturza0Adrian C. Lo1Disha Shah2Marcelo Armendáriz3Anna Vannelli4Valentina Mercaldo5Massimo Trusel6Ka Wan Li7Denise Gastaldo8Ana Rita Santos9Zsuzsanna Callaerts-Vegh10Rudi D’Hooge11Manuel Mameli12Annemie Van der Linden13August B. Smit14Tilmann Achsel15Claudia Bagni16Department of Fundamental Neurosciences, University of LausanneDepartment of Fundamental Neurosciences, University of LausanneDepartment of Biomedical Sciences, Bio-Imaging Laboratory, University of AntwerpDepartment of Neurosciences, Laboratory of Neuro- and Psychophysiology, KU LeuvenDepartment of Fundamental Neurosciences, University of LausanneDepartment of Fundamental Neurosciences, University of LausanneDepartment of Fundamental Neurosciences, University of LausanneDepartment of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University AmsterdamDepartment of Fundamental Neurosciences, University of LausanneDepartment of Human Genetics KU Leuven, VIB Center for Brain & Disease ResearchFaculty of Psychology and Educational Sciences, KU Leuven, Laboratory of Biological PsychologyFaculty of Psychology and Educational Sciences, KU Leuven, Laboratory of Biological PsychologyDepartment of Fundamental Neurosciences, University of LausanneDepartment of Biomedical Sciences, Bio-Imaging Laboratory, University of AntwerpDepartment of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University AmsterdamDepartment of Fundamental Neurosciences, University of LausanneDepartment of Fundamental Neurosciences, University of LausanneIn humans, copy-number variants of the CYFIP1 gene have been associated with autism spectrum disorders and schizophrenia. Here, the authors characterize Cyfip1-heterozygous mice, revealing that they display deficits in brain white matter structure and functional connectivity along with abnormal behaviours.https://doi.org/10.1038/s41467-019-11203-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nuria Domínguez-Iturza Adrian C. Lo Disha Shah Marcelo Armendáriz Anna Vannelli Valentina Mercaldo Massimo Trusel Ka Wan Li Denise Gastaldo Ana Rita Santos Zsuzsanna Callaerts-Vegh Rudi D’Hooge Manuel Mameli Annemie Van der Linden August B. Smit Tilmann Achsel Claudia Bagni
spellingShingle	Nuria Domínguez-Iturza Adrian C. Lo Disha Shah Marcelo Armendáriz Anna Vannelli Valentina Mercaldo Massimo Trusel Ka Wan Li Denise Gastaldo Ana Rita Santos Zsuzsanna Callaerts-Vegh Rudi D’Hooge Manuel Mameli Annemie Van der Linden August B. Smit Tilmann Achsel Claudia Bagni The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour Nature Communications
author_facet	Nuria Domínguez-Iturza Adrian C. Lo Disha Shah Marcelo Armendáriz Anna Vannelli Valentina Mercaldo Massimo Trusel Ka Wan Li Denise Gastaldo Ana Rita Santos Zsuzsanna Callaerts-Vegh Rudi D’Hooge Manuel Mameli Annemie Van der Linden August B. Smit Tilmann Achsel Claudia Bagni
author_sort	Nuria Domínguez-Iturza
title	The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
title_short	The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
title_full	The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
title_fullStr	The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
title_full_unstemmed	The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour
title_sort	autism- and schizophrenia-associated protein cyfip1 regulates bilateral brain connectivity and behaviour
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-08-01
description	In humans, copy-number variants of the CYFIP1 gene have been associated with autism spectrum disorders and schizophrenia. Here, the authors characterize Cyfip1-heterozygous mice, revealing that they display deficits in brain white matter structure and functional connectivity along with abnormal behaviours.
url	https://doi.org/10.1038/s41467-019-11203-y
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The autism- and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour

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