Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome
Abstract Background Aging, inflammation, oxidative stress, and metabolic syndrome are the main important factors in brain-derived neurotrophic factor (BDNF) level. Aim The aim of this research was to investigate the effect of 6-week aerobic exercise with moderate intensity and consumption of nano-cu...
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Online Access: | http://link.springer.com/article/10.1186/s13098-020-00532-4 |
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doaj-45d4246fbeed41b9a6bde548f29fd8b52020-11-25T02:52:09ZengBMCDiabetology & Metabolic Syndrome1758-59962020-03-011211710.1186/s13098-020-00532-4Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndromeAli Osali0Department of General Courses, University of BonabAbstract Background Aging, inflammation, oxidative stress, and metabolic syndrome are the main important factors in brain-derived neurotrophic factor (BDNF) level. Aim The aim of this research was to investigate the effect of 6-week aerobic exercise with moderate intensity and consumption of nano-curcumin on IL-6, IL-10 and BDNF in 60–65 year females with metabolic syndrome (MS). Materials and methods Forty-four women with metabolic syndrome (Mets) voluntarily took part in the present study. Participants were randomly divided into 4 groups of MetS exercise + Nano-Curcumin (MENC), MetS exercise (ME), MetS Nano-Curcumin (MNC), MetS control (MC). During the first week, MENC and ME groups participated in three sets of 10-min aerobic exercise training (AT) with a treadmill with 5-min rest parts between the sets. One minute was added to the duration of exercise sets weekly. Blood samples were collected before and after 6 weeks. IL-6, IL-10 and BDNF levels were measured by ELISA method. To analyze the data, Paired-samples t-test with the significance level of (P ≤ 0.05). Results IL-10 and BDNF concentrations significantly increased after a 6-week intervention (P ≤ 0.05). Also, IL-6 serum levels significantly decreased (P ≤ 0.05). Besides, the results of the present study suggested that nano-curcumin supplementation significantly decreases serum concentrations of malondialdehyde (MDA), and hs-CRP in subjects with metabolic syndrome. In addition, the results of the present study suggested that nano-curcumin supplementation significantly increases serum concentrations of BDNF, IL-10, and total antioxidant capacity (TAC) in subjects with metabolic syndrome. Conclusion Findings show that both of the regular exercise and consumption of NanoCurcumin for 6 weeks reduce inflammation. Combination of these two leads to even more reduction of inflammation. The regular exercise led to a decrease at the fat percentage, which deceased IL-6 level and increased IL-10 level. So, this change led to increasing BDNF’s levels. Trial registration IRCT2017082335857N1 Registered 2017-11-16, https://en.irct.ir/trial/26971http://link.springer.com/article/10.1186/s13098-020-00532-4Aerobic exerciseInflammationOxidative stressMetabolic syndromeNano-curcumin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ali Osali |
spellingShingle |
Ali Osali Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome Diabetology & Metabolic Syndrome Aerobic exercise Inflammation Oxidative stress Metabolic syndrome Nano-curcumin |
author_facet |
Ali Osali |
author_sort |
Ali Osali |
title |
Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome |
title_short |
Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome |
title_full |
Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome |
title_fullStr |
Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome |
title_full_unstemmed |
Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome |
title_sort |
aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome |
publisher |
BMC |
series |
Diabetology & Metabolic Syndrome |
issn |
1758-5996 |
publishDate |
2020-03-01 |
description |
Abstract Background Aging, inflammation, oxidative stress, and metabolic syndrome are the main important factors in brain-derived neurotrophic factor (BDNF) level. Aim The aim of this research was to investigate the effect of 6-week aerobic exercise with moderate intensity and consumption of nano-curcumin on IL-6, IL-10 and BDNF in 60–65 year females with metabolic syndrome (MS). Materials and methods Forty-four women with metabolic syndrome (Mets) voluntarily took part in the present study. Participants were randomly divided into 4 groups of MetS exercise + Nano-Curcumin (MENC), MetS exercise (ME), MetS Nano-Curcumin (MNC), MetS control (MC). During the first week, MENC and ME groups participated in three sets of 10-min aerobic exercise training (AT) with a treadmill with 5-min rest parts between the sets. One minute was added to the duration of exercise sets weekly. Blood samples were collected before and after 6 weeks. IL-6, IL-10 and BDNF levels were measured by ELISA method. To analyze the data, Paired-samples t-test with the significance level of (P ≤ 0.05). Results IL-10 and BDNF concentrations significantly increased after a 6-week intervention (P ≤ 0.05). Also, IL-6 serum levels significantly decreased (P ≤ 0.05). Besides, the results of the present study suggested that nano-curcumin supplementation significantly decreases serum concentrations of malondialdehyde (MDA), and hs-CRP in subjects with metabolic syndrome. In addition, the results of the present study suggested that nano-curcumin supplementation significantly increases serum concentrations of BDNF, IL-10, and total antioxidant capacity (TAC) in subjects with metabolic syndrome. Conclusion Findings show that both of the regular exercise and consumption of NanoCurcumin for 6 weeks reduce inflammation. Combination of these two leads to even more reduction of inflammation. The regular exercise led to a decrease at the fat percentage, which deceased IL-6 level and increased IL-10 level. So, this change led to increasing BDNF’s levels. Trial registration IRCT2017082335857N1 Registered 2017-11-16, https://en.irct.ir/trial/26971 |
topic |
Aerobic exercise Inflammation Oxidative stress Metabolic syndrome Nano-curcumin |
url |
http://link.springer.com/article/10.1186/s13098-020-00532-4 |
work_keys_str_mv |
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