Differential Effects of Dietary Patterns on Advanced Glycation end Products: A Randomized Crossover Study
Dietary advanced glycation end products (AGEs) are believed to contribute to pathogenesis of diabetes and cardiovascular disease. The objective of this study was to determine if a diet high in red and processed meat and refined grains (HMD) would elevate plasma concentrations of protein-bound AGEs c...
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doaj-45da471656ae413088552825a68212102020-11-25T03:15:30ZengMDPI AGNutrients2072-66432020-06-01121767176710.3390/nu12061767Differential Effects of Dietary Patterns on Advanced Glycation end Products: A Randomized Crossover StudyYoona Kim0Jennifer B. Keogh1Permal Deo2Peter M. Clifton3Department of Food and Nutrition, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, KoreaHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, AustraliaHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, AustraliaHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, AustraliaDietary advanced glycation end products (AGEs) are believed to contribute to pathogenesis of diabetes and cardiovascular disease. The objective of this study was to determine if a diet high in red and processed meat and refined grains (HMD) would elevate plasma concentrations of protein-bound AGEs compared with an energy-matched diet high in whole grain, dairy, nuts and legumes (HWD). We conducted a randomized crossover trial with two 4-week weight-stable dietary interventions in 51 participants without type 2 diabetes (15 men and 36 women aged 35.1 ± 15.6 y; body mass index (BMI), 27.7 ± 6.9 kg/m<sup>2</sup>). Plasma concentrations of protein-bound Nε-(carboxymethyl) lysine (CML), Nε-(1-carboxyethyl) lysine (CEL) and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were measured by liquid chromatography–tandem mass spectrometry (LC-MS/MS). The HMD significantly increased plasma concentrations (nmol/mL) of CEL (1.367, 0.78 vs. 1.096, 0.65; <i>p</i> < 0.01; <i>n</i> = 48) compared with the HWD. No differences in CML and MG-H1 between HMD and HWD were observed. HMD increased plasma CEL concentrations compared with HWD in individuals without type 2 diabetes.https://www.mdpi.com/2072-6643/12/6/1767dietary advanced glycation productscarboxymethyl–lysine (CML)carboxyethyl–lysine (CEL)methylglyoxal–hydroimidazalone (MG-H1) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoona Kim Jennifer B. Keogh Permal Deo Peter M. Clifton |
spellingShingle |
Yoona Kim Jennifer B. Keogh Permal Deo Peter M. Clifton Differential Effects of Dietary Patterns on Advanced Glycation end Products: A Randomized Crossover Study Nutrients dietary advanced glycation products carboxymethyl–lysine (CML) carboxyethyl–lysine (CEL) methylglyoxal–hydroimidazalone (MG-H1) |
author_facet |
Yoona Kim Jennifer B. Keogh Permal Deo Peter M. Clifton |
author_sort |
Yoona Kim |
title |
Differential Effects of Dietary Patterns on Advanced Glycation end Products: A Randomized Crossover Study |
title_short |
Differential Effects of Dietary Patterns on Advanced Glycation end Products: A Randomized Crossover Study |
title_full |
Differential Effects of Dietary Patterns on Advanced Glycation end Products: A Randomized Crossover Study |
title_fullStr |
Differential Effects of Dietary Patterns on Advanced Glycation end Products: A Randomized Crossover Study |
title_full_unstemmed |
Differential Effects of Dietary Patterns on Advanced Glycation end Products: A Randomized Crossover Study |
title_sort |
differential effects of dietary patterns on advanced glycation end products: a randomized crossover study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-06-01 |
description |
Dietary advanced glycation end products (AGEs) are believed to contribute to pathogenesis of diabetes and cardiovascular disease. The objective of this study was to determine if a diet high in red and processed meat and refined grains (HMD) would elevate plasma concentrations of protein-bound AGEs compared with an energy-matched diet high in whole grain, dairy, nuts and legumes (HWD). We conducted a randomized crossover trial with two 4-week weight-stable dietary interventions in 51 participants without type 2 diabetes (15 men and 36 women aged 35.1 ± 15.6 y; body mass index (BMI), 27.7 ± 6.9 kg/m<sup>2</sup>). Plasma concentrations of protein-bound Nε-(carboxymethyl) lysine (CML), Nε-(1-carboxyethyl) lysine (CEL) and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were measured by liquid chromatography–tandem mass spectrometry (LC-MS/MS). The HMD significantly increased plasma concentrations (nmol/mL) of CEL (1.367, 0.78 vs. 1.096, 0.65; <i>p</i> < 0.01; <i>n</i> = 48) compared with the HWD. No differences in CML and MG-H1 between HMD and HWD were observed. HMD increased plasma CEL concentrations compared with HWD in individuals without type 2 diabetes. |
topic |
dietary advanced glycation products carboxymethyl–lysine (CML) carboxyethyl–lysine (CEL) methylglyoxal–hydroimidazalone (MG-H1) |
url |
https://www.mdpi.com/2072-6643/12/6/1767 |
work_keys_str_mv |
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