Pulmonary and ventricular functions in children with repaired tetralogy of Fallot
OBJECTIVE: This study aimed to evaluate biventricular function, brain natriuretic peptide levels, respiratory function test and 6 minute walking test (6MWT) in children with repaired tetralogy of Fallot (TOF), and analyse the correlation between these variables and clinical status. METHODS: Twenty...
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2015-09-01
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doaj-45db4f4dc1704252b5a0b8d41f5fb2352021-01-19T07:41:27ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692015-09-0143654255010.5543/tkda.2015.52498TKDA-52498Pulmonary and ventricular functions in children with repaired tetralogy of FallotSavaş Demirpençe0Barış Güven1Murat Muhtar Yılmazer2Taliha Öner3Önder Doksöz4Rahmi Özdemir5Hikmet Tekin Nacaroğlu6Timur Meşe7Vedide Tavlı8Demet Can9Sifa University Faculty of Medicine, Department of Pediatric Cardiology, Bornova, Izmir, TurkeyIzmir University Faculty of Medicine, Medical Park Hospital, Department of Pediatric Cardiology, Karşıyaka, Izmir, TurkeyBehçet Uz Children Hospital, Departments of Pediatric Cardiology, Alsancak, Izmir, TurkeyBehçet Uz Children Hospital, Departments of Pediatric Cardiology, Alsancak, Izmir, TurkeyBehçet Uz Children Hospital, Departments of Pediatric Cardiology, Alsancak, Izmir, TurkeyBehçet Uz Children Hospital, Departments of Pediatric Cardiology, Alsancak, Izmir, TurkeyBehçet Uz Children Hospital, Departments of Pediatric Allergy and Immunology, Alsancak, Izmir, TurkeyBehçet Uz Children Hospital, Departments of Pediatric Cardiology, Alsancak, Izmir, TurkeySifa University Faculty of Medicine, Department of Pediatric Cardiology, Bornova, Izmir, TurkeyBehçet Uz Children Hospital, Departments of Pediatric Allergy and Immunology, Alsancak, Izmir, TurkeyOBJECTIVE: This study aimed to evaluate biventricular function, brain natriuretic peptide levels, respiratory function test and 6 minute walking test (6MWT) in children with repaired tetralogy of Fallot (TOF), and analyse the correlation between these variables and clinical status. METHODS: Twenty-five children (14 boys, 11 girls; aged 6 to 17 years) with repaired TOF (Group 1) and 25 age-sex matched healthy controls (Group 2) were enrolled in the study. Tissue Doppler echocardiography, respiratory function test, 6MWT distance and brain natriuretic peptide levels were measured. RESULTS: Mean ages of the children at TOF corrective surgery and at study time were 5.1+-3.5 years and 11.6+-2.7 years respectively. The duration between palliative operation and corrective surgery was 4.3+-2.0 years, and the follow-up period after corrective surgery was 6.3+-3.0 years. The right ventricular and left ventricular myocardial performance indices (MPIs), and isovolumic relaxation and contraction times were significantly higher in Group 1 than in Group 2 (p<0.01). Spirometry displayed significantly reduced forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory flow 25–75% (FEF25–75) and inspirational capacity in Group 1 compared to Group 2 (p<0.01). In Group 1, 6MWT distances were significantly lower than in Group 2 (p=0.001). Right ventricular MPI is correlated with FEV1, FVC and 6MWT distance in the current study. CONCLUSION: The children with repaired TOF had impaired ventricular and pulmonary functions. Hence, right ventricular MPI along with FEV1, FVC and 6MWT distance may be useful in the follow-up of children with repaired TOF.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-52498natriuretic peptidebraintetralogy of fallottissue doppler echocardiographysix minute walking test; respiratory function test |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Savaş Demirpençe Barış Güven Murat Muhtar Yılmazer Taliha Öner Önder Doksöz Rahmi Özdemir Hikmet Tekin Nacaroğlu Timur Meşe Vedide Tavlı Demet Can |
spellingShingle |
Savaş Demirpençe Barış Güven Murat Muhtar Yılmazer Taliha Öner Önder Doksöz Rahmi Özdemir Hikmet Tekin Nacaroğlu Timur Meşe Vedide Tavlı Demet Can Pulmonary and ventricular functions in children with repaired tetralogy of Fallot Türk Kardiyoloji Derneği Arşivi natriuretic peptide brain tetralogy of fallot tissue doppler echocardiography six minute walking test; respiratory function test |
author_facet |
Savaş Demirpençe Barış Güven Murat Muhtar Yılmazer Taliha Öner Önder Doksöz Rahmi Özdemir Hikmet Tekin Nacaroğlu Timur Meşe Vedide Tavlı Demet Can |
author_sort |
Savaş Demirpençe |
title |
Pulmonary and ventricular functions in children with repaired tetralogy of Fallot |
title_short |
Pulmonary and ventricular functions in children with repaired tetralogy of Fallot |
title_full |
Pulmonary and ventricular functions in children with repaired tetralogy of Fallot |
title_fullStr |
Pulmonary and ventricular functions in children with repaired tetralogy of Fallot |
title_full_unstemmed |
Pulmonary and ventricular functions in children with repaired tetralogy of Fallot |
title_sort |
pulmonary and ventricular functions in children with repaired tetralogy of fallot |
publisher |
KARE Publishing |
series |
Türk Kardiyoloji Derneği Arşivi |
issn |
1016-5169 |
publishDate |
2015-09-01 |
description |
OBJECTIVE: This study aimed to evaluate biventricular function, brain natriuretic peptide levels, respiratory function test and 6 minute walking test (6MWT) in children with repaired tetralogy of Fallot (TOF), and analyse the correlation between these variables and clinical status.
METHODS: Twenty-five children (14 boys, 11 girls; aged 6 to 17 years) with repaired TOF (Group 1) and 25 age-sex matched healthy controls (Group 2) were enrolled in the study. Tissue Doppler echocardiography, respiratory function test, 6MWT distance and brain natriuretic peptide levels were measured.
RESULTS: Mean ages of the children at TOF corrective surgery and at study time were 5.1+-3.5 years and 11.6+-2.7 years respectively. The duration between palliative operation and corrective surgery was 4.3+-2.0 years, and the follow-up period after corrective surgery was 6.3+-3.0 years. The right ventricular and left ventricular myocardial performance indices (MPIs), and isovolumic relaxation and contraction times were significantly higher in Group 1 than in Group 2 (p<0.01). Spirometry displayed significantly reduced forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory flow 25–75% (FEF25–75) and inspirational capacity in Group 1 compared to Group 2 (p<0.01). In Group 1, 6MWT distances were significantly lower than in Group 2 (p=0.001). Right ventricular MPI is correlated with FEV1, FVC and 6MWT distance in the current study.
CONCLUSION: The children with repaired TOF had impaired ventricular and pulmonary functions. Hence, right ventricular MPI along with FEV1, FVC and 6MWT distance may be useful in the follow-up of children with repaired TOF. |
topic |
natriuretic peptide brain tetralogy of fallot tissue doppler echocardiography six minute walking test; respiratory function test |
url |
https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-52498 |
work_keys_str_mv |
AT savasdemirpence pulmonaryandventricularfunctionsinchildrenwithrepairedtetralogyoffallot AT barısguven pulmonaryandventricularfunctionsinchildrenwithrepairedtetralogyoffallot AT muratmuhtaryılmazer pulmonaryandventricularfunctionsinchildrenwithrepairedtetralogyoffallot AT talihaoner pulmonaryandventricularfunctionsinchildrenwithrepairedtetralogyoffallot AT onderdoksoz pulmonaryandventricularfunctionsinchildrenwithrepairedtetralogyoffallot AT rahmiozdemir pulmonaryandventricularfunctionsinchildrenwithrepairedtetralogyoffallot AT hikmettekinnacaroglu pulmonaryandventricularfunctionsinchildrenwithrepairedtetralogyoffallot AT timurmese pulmonaryandventricularfunctionsinchildrenwithrepairedtetralogyoffallot AT vedidetavlı pulmonaryandventricularfunctionsinchildrenwithrepairedtetralogyoffallot AT demetcan pulmonaryandventricularfunctionsinchildrenwithrepairedtetralogyoffallot |
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