Influence of Probiotics on the Development of <i>Clostridioides difficile</i> Infection in Patients Receiving Fluoroquinolones
Fluoroquinolones are associated with an increased risk of <i>Clostridioides difficile</i> infection (CDI). Probiotic supplementation has been shown to reduce the risk of antibiotic-associated diarrhea with variable effects on CDI. The objective of this study was to evaluate receipt of pr...
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doaj-45ef4e9d429f488986ba4f57f252bff22021-09-26T00:57:34ZengMDPI AGPharmacy2226-47872021-08-01914114110.3390/pharmacy9030141Influence of Probiotics on the Development of <i>Clostridioides difficile</i> Infection in Patients Receiving FluoroquinolonesMary E. Sheffield0Bruce M. Jones1Blake Terrell2Jamie L. Wagner3Christopher M. Bland4St. Joseph’s/Candler Health System, Savannah, GA 31405, USASt. Joseph’s/Candler Health System, Savannah, GA 31405, USADepartment of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Savannah, GA 31324, USADepartment of Pharmacy Practice, University of Mississippi School of Pharmacy, Jackson, MS 39216, USASt. Joseph’s/Candler Health System, Savannah, GA 31405, USAFluoroquinolones are associated with an increased risk of <i>Clostridioides difficile</i> infection (CDI). Probiotic supplementation has been shown to reduce the risk of antibiotic-associated diarrhea with variable effects on CDI. The objective of this study was to evaluate receipt of probiotics on development of primary CDI among hospitalized patients receiving fluoroquinolones. A retrospective cohort was evaluated that consisted of two groups of 100 patients each, admitted August 2018 through August 2020 that received ≥3 days of definitive monotherapy with levofloxacin or ciprofloxacin within 72 h of admission. Primary outcome was incidence of CDI. Secondary outcomes included rates of <i>C. difficile</i> diagnostic stool testing, additional infectious diagnostic testing, and non-CDI related gastrointestinal side effects. Patients on fluoroquinolones who received probiotics had a non-statistically significantly lower incidence in overall cases of CDI compared to those who did not receive probiotics (0% vs. 3%, <i>p</i> = 0.246). Patients who received probiotics had statistically significantly fewer <i>C. difficile</i> diagnostic stool tests performed (4% vs. 16%, <i>p</i> = 0.005) and fewer additional infectious diagnostic testing performed (4% vs. 10%, <i>p</i> = 0.096), respectively. Further research is warranted to optimize and standardize probiotic prescribing in high-risk patients.https://www.mdpi.com/2226-4787/9/3/141antibiotic-associated diarrheaCDIciprofloxacin<i>Clostridioides difficile</i>levofloxacinprobiotics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mary E. Sheffield Bruce M. Jones Blake Terrell Jamie L. Wagner Christopher M. Bland |
spellingShingle |
Mary E. Sheffield Bruce M. Jones Blake Terrell Jamie L. Wagner Christopher M. Bland Influence of Probiotics on the Development of <i>Clostridioides difficile</i> Infection in Patients Receiving Fluoroquinolones Pharmacy antibiotic-associated diarrhea CDI ciprofloxacin <i>Clostridioides difficile</i> levofloxacin probiotics |
author_facet |
Mary E. Sheffield Bruce M. Jones Blake Terrell Jamie L. Wagner Christopher M. Bland |
author_sort |
Mary E. Sheffield |
title |
Influence of Probiotics on the Development of <i>Clostridioides difficile</i> Infection in Patients Receiving Fluoroquinolones |
title_short |
Influence of Probiotics on the Development of <i>Clostridioides difficile</i> Infection in Patients Receiving Fluoroquinolones |
title_full |
Influence of Probiotics on the Development of <i>Clostridioides difficile</i> Infection in Patients Receiving Fluoroquinolones |
title_fullStr |
Influence of Probiotics on the Development of <i>Clostridioides difficile</i> Infection in Patients Receiving Fluoroquinolones |
title_full_unstemmed |
Influence of Probiotics on the Development of <i>Clostridioides difficile</i> Infection in Patients Receiving Fluoroquinolones |
title_sort |
influence of probiotics on the development of <i>clostridioides difficile</i> infection in patients receiving fluoroquinolones |
publisher |
MDPI AG |
series |
Pharmacy |
issn |
2226-4787 |
publishDate |
2021-08-01 |
description |
Fluoroquinolones are associated with an increased risk of <i>Clostridioides difficile</i> infection (CDI). Probiotic supplementation has been shown to reduce the risk of antibiotic-associated diarrhea with variable effects on CDI. The objective of this study was to evaluate receipt of probiotics on development of primary CDI among hospitalized patients receiving fluoroquinolones. A retrospective cohort was evaluated that consisted of two groups of 100 patients each, admitted August 2018 through August 2020 that received ≥3 days of definitive monotherapy with levofloxacin or ciprofloxacin within 72 h of admission. Primary outcome was incidence of CDI. Secondary outcomes included rates of <i>C. difficile</i> diagnostic stool testing, additional infectious diagnostic testing, and non-CDI related gastrointestinal side effects. Patients on fluoroquinolones who received probiotics had a non-statistically significantly lower incidence in overall cases of CDI compared to those who did not receive probiotics (0% vs. 3%, <i>p</i> = 0.246). Patients who received probiotics had statistically significantly fewer <i>C. difficile</i> diagnostic stool tests performed (4% vs. 16%, <i>p</i> = 0.005) and fewer additional infectious diagnostic testing performed (4% vs. 10%, <i>p</i> = 0.096), respectively. Further research is warranted to optimize and standardize probiotic prescribing in high-risk patients. |
topic |
antibiotic-associated diarrhea CDI ciprofloxacin <i>Clostridioides difficile</i> levofloxacin probiotics |
url |
https://www.mdpi.com/2226-4787/9/3/141 |
work_keys_str_mv |
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