Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis
Abstract Objective To investigate whether preoperative localization of sentinel lymph node (SLN) by contrast-enhanced ultrasound (CEUS) can further improve the accuracy of sentinel lymph node biopsy (SLNB). Method Collect published literatures or conference reports by searching electronic databases....
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doaj-45f419aecacc4c3ab48bcb9cbec95c292020-11-25T03:18:26ZengBMCWorld Journal of Surgical Oncology1477-78192020-05-0118111110.1186/s12957-020-01890-zAccuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysisQiuxia Cui0Li Dai1Jialu Li2Jialei Xue3Department of Thyroid and Breast Surgery, Changshu Hospital Affiliated to Nanjing University of Chinese MedicineDepartment of Thyroid and Breast Surgery, Changshu Hospital Affiliated to Nanjing University of Chinese MedicineDepartment of Thyroid and Breast Surgery, Changshu Hospital Affiliated to Nanjing University of Chinese MedicineDepartment of Thyroid and Breast Surgery, Changshu Hospital Affiliated to Nanjing University of Chinese MedicineAbstract Objective To investigate whether preoperative localization of sentinel lymph node (SLN) by contrast-enhanced ultrasound (CEUS) can further improve the accuracy of sentinel lymph node biopsy (SLNB). Method Collect published literatures or conference reports by searching electronic databases. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) evaluation method is used to evaluate the quality of the screened literatures. The pooled risk ratio of cancer metastasis of SLN identified by CEUS (CE-SLN) compared with SLN not identified by CEUS (nonCE-SLN) is calculated, and the pooled diagnostic accuracy of CE-SLN for pathological status of all SLNs is also evaluated. Result Through search and screening, a total of 16 studies were included, of which five and seven studies, respectively, entered the meta-analysis of metastatic risk ratio and diagnostic accuracy. The localization rate of preoperative CEUS for sentinel lymph nodes was 70 to 100%. The meta-analysis shows that the risk of metastasis of SLN identified by CEUS is significantly higher than that not identified by CEUS, 26.0% vs 4.6%, and risk ratio (RR) is 6.08 (95% CI 4.17–8.85). In early-stage breast cancer, the pathological status of CE-SLN is a good representative of all SLNs, with a pooled sensitivity of 98% (95% CI 0.94–1.00), pooled specificity of 100% (95% CI 0.99–1.00), diagnostic odds ratio (DOR) of 2153.18 (95% CI 476.53–9729.06), and area under the subject receiver operating characteristic (SROC) curve of 0.9968. Conclusion In early-stage breast cancer, preoperative localization of SLN by CEUS is expected to further improve the accuracy of sentinel lymph node biopsy (SLNB).http://link.springer.com/article/10.1186/s12957-020-01890-zBreast cancerContrast-enhanced ultrasoundMicrobubbleSentinel lymph nodeSentinel lymph node biopsyDiagnostic accuracy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiuxia Cui Li Dai Jialu Li Jialei Xue |
spellingShingle |
Qiuxia Cui Li Dai Jialu Li Jialei Xue Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis World Journal of Surgical Oncology Breast cancer Contrast-enhanced ultrasound Microbubble Sentinel lymph node Sentinel lymph node biopsy Diagnostic accuracy |
author_facet |
Qiuxia Cui Li Dai Jialu Li Jialei Xue |
author_sort |
Qiuxia Cui |
title |
Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis |
title_short |
Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis |
title_full |
Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis |
title_fullStr |
Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis |
title_full_unstemmed |
Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis |
title_sort |
accuracy of ceus-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis |
publisher |
BMC |
series |
World Journal of Surgical Oncology |
issn |
1477-7819 |
publishDate |
2020-05-01 |
description |
Abstract Objective To investigate whether preoperative localization of sentinel lymph node (SLN) by contrast-enhanced ultrasound (CEUS) can further improve the accuracy of sentinel lymph node biopsy (SLNB). Method Collect published literatures or conference reports by searching electronic databases. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) evaluation method is used to evaluate the quality of the screened literatures. The pooled risk ratio of cancer metastasis of SLN identified by CEUS (CE-SLN) compared with SLN not identified by CEUS (nonCE-SLN) is calculated, and the pooled diagnostic accuracy of CE-SLN for pathological status of all SLNs is also evaluated. Result Through search and screening, a total of 16 studies were included, of which five and seven studies, respectively, entered the meta-analysis of metastatic risk ratio and diagnostic accuracy. The localization rate of preoperative CEUS for sentinel lymph nodes was 70 to 100%. The meta-analysis shows that the risk of metastasis of SLN identified by CEUS is significantly higher than that not identified by CEUS, 26.0% vs 4.6%, and risk ratio (RR) is 6.08 (95% CI 4.17–8.85). In early-stage breast cancer, the pathological status of CE-SLN is a good representative of all SLNs, with a pooled sensitivity of 98% (95% CI 0.94–1.00), pooled specificity of 100% (95% CI 0.99–1.00), diagnostic odds ratio (DOR) of 2153.18 (95% CI 476.53–9729.06), and area under the subject receiver operating characteristic (SROC) curve of 0.9968. Conclusion In early-stage breast cancer, preoperative localization of SLN by CEUS is expected to further improve the accuracy of sentinel lymph node biopsy (SLNB). |
topic |
Breast cancer Contrast-enhanced ultrasound Microbubble Sentinel lymph node Sentinel lymph node biopsy Diagnostic accuracy |
url |
http://link.springer.com/article/10.1186/s12957-020-01890-z |
work_keys_str_mv |
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