Different Approaches in Therapy Aiming to Stabilize An Unstable Atherosclerotic Plaque
Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to rupture, which results in atherosclerosis complications—myocardial infarctions and subsequent cardiovascular deaths. Therefore, methods aiming to stabilize such plaques are in great demand. In this brief r...
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doaj-45f56a416b6e4b4491ee310d192ddb0d2021-04-21T23:07:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01224354435410.3390/ijms22094354Different Approaches in Therapy Aiming to Stabilize An Unstable Atherosclerotic PlaqueMichal Kowara0Agnieszka Cudnoch-Jedrzejewska1Chair and Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 02-091 Warsaw, PolandChair and Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 02-091 Warsaw, PolandAtherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to rupture, which results in atherosclerosis complications—myocardial infarctions and subsequent cardiovascular deaths. Therefore, methods aiming to stabilize such plaques are in great demand. In this brief review, the idea of atherosclerotic plaque stabilization and five main approaches—towards the regulation of metabolism, macrophages and cellular death, inflammation, reactive oxygen species, and extracellular matrix remodeling have been presented. Moreover, apart from classical approaches (targeted at the general mechanisms of plaque destabilization), there are also alternative approaches targeted either at certain plaques which have just become vulnerable or targeted at the minimization of the consequences of atherosclerotic plaque erosion or rupture. These alternative approaches have also been briefly mentioned in this review.https://www.mdpi.com/1422-0067/22/9/4354atherosclerotic plaquestabilizationvulnerable plaqueinflammationmacrophageintravascular ultrasound |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michal Kowara Agnieszka Cudnoch-Jedrzejewska |
spellingShingle |
Michal Kowara Agnieszka Cudnoch-Jedrzejewska Different Approaches in Therapy Aiming to Stabilize An Unstable Atherosclerotic Plaque International Journal of Molecular Sciences atherosclerotic plaque stabilization vulnerable plaque inflammation macrophage intravascular ultrasound |
author_facet |
Michal Kowara Agnieszka Cudnoch-Jedrzejewska |
author_sort |
Michal Kowara |
title |
Different Approaches in Therapy Aiming to Stabilize An Unstable Atherosclerotic Plaque |
title_short |
Different Approaches in Therapy Aiming to Stabilize An Unstable Atherosclerotic Plaque |
title_full |
Different Approaches in Therapy Aiming to Stabilize An Unstable Atherosclerotic Plaque |
title_fullStr |
Different Approaches in Therapy Aiming to Stabilize An Unstable Atherosclerotic Plaque |
title_full_unstemmed |
Different Approaches in Therapy Aiming to Stabilize An Unstable Atherosclerotic Plaque |
title_sort |
different approaches in therapy aiming to stabilize an unstable atherosclerotic plaque |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-04-01 |
description |
Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to rupture, which results in atherosclerosis complications—myocardial infarctions and subsequent cardiovascular deaths. Therefore, methods aiming to stabilize such plaques are in great demand. In this brief review, the idea of atherosclerotic plaque stabilization and five main approaches—towards the regulation of metabolism, macrophages and cellular death, inflammation, reactive oxygen species, and extracellular matrix remodeling have been presented. Moreover, apart from classical approaches (targeted at the general mechanisms of plaque destabilization), there are also alternative approaches targeted either at certain plaques which have just become vulnerable or targeted at the minimization of the consequences of atherosclerotic plaque erosion or rupture. These alternative approaches have also been briefly mentioned in this review. |
topic |
atherosclerotic plaque stabilization vulnerable plaque inflammation macrophage intravascular ultrasound |
url |
https://www.mdpi.com/1422-0067/22/9/4354 |
work_keys_str_mv |
AT michalkowara differentapproachesintherapyaimingtostabilizeanunstableatheroscleroticplaque AT agnieszkacudnochjedrzejewska differentapproachesintherapyaimingtostabilizeanunstableatheroscleroticplaque |
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1721515208588918784 |