Intergenerational effect of short-term spaceflight in mice
Summary: As space travel becomes more accessible, it is important to understand the effects of spaceflight including microgravity, cosmic radiation, and psychological stress. However, the effect on offspring has not been well studied in mammals. Here we investigated the effect of 35 days spaceflight...
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doaj-4606457e2f5149068546b397dc48fd332021-07-23T04:50:32ZengElsevieriScience2589-00422021-07-01247102773Intergenerational effect of short-term spaceflight in miceKeisuke Yoshida0Shin-ichiro Fujita1Ayako Isotani2Takashi Kudo3Satoru Takahashi4Masahito Ikawa5Dai Shiba6Masaki Shirakawa7Masafumi Muratani8Shunsuke Ishii9RIKEN Cluster for Pioneering Research, Tsukuba, Ibaraki 305-0074, Japan; Corresponding authorDepartment of Genome Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, JapanDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, JapanLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, JapanLaboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, JapanDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, JapanMouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki 305-8505, JapanMouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki 305-8505, JapanDepartment of Genome Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, JapanRIKEN Cluster for Pioneering Research, Tsukuba, Ibaraki 305-0074, Japan; Department of Functional Genomics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, JapanSummary: As space travel becomes more accessible, it is important to understand the effects of spaceflight including microgravity, cosmic radiation, and psychological stress. However, the effect on offspring has not been well studied in mammals. Here we investigated the effect of 35 days spaceflight on male germ cells. Male mice that had experienced spaceflight exhibit alterations in binding of transcription factor ATF7, a regulator of heterochromatin formation, on promoter regions in testis, as well as altered small RNA expression in spermatozoa. Offspring of space-traveling males exhibit elevated hepatic expression of genes related to DNA replication. These results indicate that spaceflight has intergenerational effect.http://www.sciencedirect.com/science/article/pii/S2589004221007410TranscriptomicsSpace sciences |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Keisuke Yoshida Shin-ichiro Fujita Ayako Isotani Takashi Kudo Satoru Takahashi Masahito Ikawa Dai Shiba Masaki Shirakawa Masafumi Muratani Shunsuke Ishii |
spellingShingle |
Keisuke Yoshida Shin-ichiro Fujita Ayako Isotani Takashi Kudo Satoru Takahashi Masahito Ikawa Dai Shiba Masaki Shirakawa Masafumi Muratani Shunsuke Ishii Intergenerational effect of short-term spaceflight in mice iScience Transcriptomics Space sciences |
author_facet |
Keisuke Yoshida Shin-ichiro Fujita Ayako Isotani Takashi Kudo Satoru Takahashi Masahito Ikawa Dai Shiba Masaki Shirakawa Masafumi Muratani Shunsuke Ishii |
author_sort |
Keisuke Yoshida |
title |
Intergenerational effect of short-term spaceflight in mice |
title_short |
Intergenerational effect of short-term spaceflight in mice |
title_full |
Intergenerational effect of short-term spaceflight in mice |
title_fullStr |
Intergenerational effect of short-term spaceflight in mice |
title_full_unstemmed |
Intergenerational effect of short-term spaceflight in mice |
title_sort |
intergenerational effect of short-term spaceflight in mice |
publisher |
Elsevier |
series |
iScience |
issn |
2589-0042 |
publishDate |
2021-07-01 |
description |
Summary: As space travel becomes more accessible, it is important to understand the effects of spaceflight including microgravity, cosmic radiation, and psychological stress. However, the effect on offspring has not been well studied in mammals. Here we investigated the effect of 35 days spaceflight on male germ cells. Male mice that had experienced spaceflight exhibit alterations in binding of transcription factor ATF7, a regulator of heterochromatin formation, on promoter regions in testis, as well as altered small RNA expression in spermatozoa. Offspring of space-traveling males exhibit elevated hepatic expression of genes related to DNA replication. These results indicate that spaceflight has intergenerational effect. |
topic |
Transcriptomics Space sciences |
url |
http://www.sciencedirect.com/science/article/pii/S2589004221007410 |
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