The Key Enzyme of the Sialic Acid Metabolism Is Involved in Embryoid Body Formation and Expression of Marker Genes of Germ Layer Formation

The Key Enzyme of the Sialic Acid Metabolism Is Involved in Embryoid Body Formation and Expression of Marker Genes of Germ Layer Formation

The bi-functional enzyme UDP-N-acetyl-2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme of the sialic acid biosynthesis. Sialic acids are negatively charged nine carbon amino sugars and are found on most glycoproteins and many glycolipids in terminal positions, where they are involved i...

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Bibliographic Details
Main Authors: Annett Thate, Rüdiger Horstkorte, Dorit Bennmann, Jessica Hering, Wenke Weidemann
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:International Journal of Molecular Sciences
Subjects:
sialic acid biosynthesis
UDP-N-acetyl-2-epimerase/N-acetylmannosamine kinase
embryonic stem cells
embryoid bodies
gene expression
Online Access:http://www.mdpi.com/1422-0067/14/10/20555

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