Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses

Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses

Scarring and regeneration are two physiologically opposite endpoints to skin injuries, with mammals, including humans, typically healing wounds with fibrotic scars. We aim to provide an updated review on fibroblast heterogeneity as determinants of the scarring−regeneration continuum. We di...

Full description

Bibliographic Details
Main Authors: Dongsheng Jiang, Yuval Rinkevich
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
scarring
fibrosis
fibroblasts
regeneration
adhesion
Online Access:https://www.mdpi.com/1422-0067/21/2/617
id doaj-46115e2139fa45c58748b44f8bb014cd
record_format Article
spelling doaj-46115e2139fa45c58748b44f8bb014cd2020-11-25T01:10:11ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-01-0121261710.3390/ijms21020617ijms21020617Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound ResponsesDongsheng Jiang0Yuval Rinkevich1Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Max-Lebsche-Platz 31, 81377 Munich, GermanyComprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Max-Lebsche-Platz 31, 81377 Munich, GermanyScarring and regeneration are two physiologically opposite endpoints to skin injuries, with mammals, including humans, typically healing wounds with fibrotic scars. We aim to provide an updated review on fibroblast heterogeneity as determinants of the scarring−regeneration continuum. We discuss fibroblast-centric mechanisms that dictate scarring−regeneration continua with a focus on intercellular and cell−matrix adhesion. Improved understanding of fibroblast lineage-specific mechanisms and how they determine scar severity will ultimately allow for the development of antiscarring therapies and the promotion of tissue regeneration.https://www.mdpi.com/1422-0067/21/2/617scarringfibrosisfibroblastsregenerationadhesion
collection DOAJ
language English
format Article
sources DOAJ
author Dongsheng Jiang
Yuval Rinkevich
spellingShingle Dongsheng Jiang
Yuval Rinkevich
Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses
International Journal of Molecular Sciences
scarring
fibrosis
fibroblasts
regeneration
adhesion
author_facet Dongsheng Jiang
Yuval Rinkevich
author_sort Dongsheng Jiang
title Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses
title_short Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses
title_full Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses
title_fullStr Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses
title_full_unstemmed Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses
title_sort scars or regeneration?—dermal fibroblasts as drivers of diverse skin wound responses
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2020-01-01
description Scarring and regeneration are two physiologically opposite endpoints to skin injuries, with mammals, including humans, typically healing wounds with fibrotic scars. We aim to provide an updated review on fibroblast heterogeneity as determinants of the scarring−regeneration continuum. We discuss fibroblast-centric mechanisms that dictate scarring−regeneration continua with a focus on intercellular and cell−matrix adhesion. Improved understanding of fibroblast lineage-specific mechanisms and how they determine scar severity will ultimately allow for the development of antiscarring therapies and the promotion of tissue regeneration.
topic scarring
fibrosis
fibroblasts
regeneration
adhesion
url https://www.mdpi.com/1422-0067/21/2/617
work_keys_str_mv AT dongshengjiang scarsorregenerationdermalfibroblastsasdriversofdiverseskinwoundresponses
AT yuvalrinkevich scarsorregenerationdermalfibroblastsasdriversofdiverseskinwoundresponses
_version_ 1725176260537090048

Similar Items