Oxidative Stress, Fibrosis, and Early Afterdepolarization-Mediated Cardiac Arrhythmias
Animal and clinical studies have demonstrated that oxidative stress, a common pathophysiological factor in cardiac disease, reduces repolarization reserve by enhancing the L-type calcium current, the late Na, and the Na-Ca exchanger, promoting early afterdepolarizations (EADs) that can initiate vent...
Main Authors: | Hrayr eKaragueuzian, Thao P Nguyen, Zhilin eQu, James N Weiss |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2013-02-01
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Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00019/full |
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