The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop

The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop

Progression of the cell division cycle requires feedback loops including those of phosphorylation and dephosphorylation; however the precise regulation of phosphorylation kinetics of Arpp19, an inhibitor of protein phosphatase 2A, is unclear. Here, the authors report that feedback between phosphoryl...

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Main Authors: Jean Claude Labbé, Suzanne Vigneron, Francisca Méchali, Perle Robert, Sylvain Roque, Cindy Genoud, Perrine Goguet-Rubio, Phillipe Barthe, Gilles Labesse, Martin Cohen-Gonsaud, Anna Castro, Thierry Lorca
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23657-0
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spelling doaj-4630ed5bbeb04a7d806c2473f1f9022d2021-06-13T11:16:46ZengNature Publishing GroupNature Communications2041-17232021-06-0112111910.1038/s41467-021-23657-0The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loopJean Claude Labbé0Suzanne Vigneron1Francisca Méchali2Perle Robert3Sylvain Roque4Cindy Genoud5Perrine Goguet-Rubio6Phillipe Barthe7Gilles Labesse8Martin Cohen-Gonsaud9Anna Castro10Thierry Lorca11Université de Montpellier, Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM) CNRS, UMR 5237Université de Montpellier, Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM) CNRS, UMR 5237Université de Montpellier, Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM) CNRS, UMR 5237Université de Montpellier, Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM) CNRS, UMR 5237Université de Montpellier, Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM) CNRS, UMR 5237Université de Montpellier, Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM) CNRS, UMR 5237Université de Montpellier, Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM) CNRS, UMR 5237Centre de Biologie Structurale (CBS), CNRS, INSERM, Université de MontpellierCentre de Biologie Structurale (CBS), CNRS, INSERM, Université de MontpellierCentre de Biologie Structurale (CBS), CNRS, INSERM, Université de MontpellierUniversité de Montpellier, Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM) CNRS, UMR 5237Université de Montpellier, Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM) CNRS, UMR 5237Progression of the cell division cycle requires feedback loops including those of phosphorylation and dephosphorylation; however the precise regulation of phosphorylation kinetics of Arpp19, an inhibitor of protein phosphatase 2A, is unclear. Here, the authors report that feedback between phosphorylation states of Ser67 and Ser109 of Arpp19 coordinates Arpp19-dependent inhibition of PP2A-B55 and Cyclin B activation during cell cycle progression.https://doi.org/10.1038/s41467-021-23657-0
collection DOAJ
language English
format Article
sources DOAJ
author Jean Claude Labbé
Suzanne Vigneron
Francisca Méchali
Perle Robert
Sylvain Roque
Cindy Genoud
Perrine Goguet-Rubio
Phillipe Barthe
Gilles Labesse
Martin Cohen-Gonsaud
Anna Castro
Thierry Lorca
spellingShingle Jean Claude Labbé
Suzanne Vigneron
Francisca Méchali
Perle Robert
Sylvain Roque
Cindy Genoud
Perrine Goguet-Rubio
Phillipe Barthe
Gilles Labesse
Martin Cohen-Gonsaud
Anna Castro
Thierry Lorca
The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
Nature Communications
author_facet Jean Claude Labbé
Suzanne Vigneron
Francisca Méchali
Perle Robert
Sylvain Roque
Cindy Genoud
Perrine Goguet-Rubio
Phillipe Barthe
Gilles Labesse
Martin Cohen-Gonsaud
Anna Castro
Thierry Lorca
author_sort Jean Claude Labbé
title The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
title_short The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
title_full The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
title_fullStr The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
title_full_unstemmed The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
title_sort study of the determinants controlling arpp19 phosphatase-inhibitory activity reveals an arpp19/pp2a-b55 feedback loop
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description Progression of the cell division cycle requires feedback loops including those of phosphorylation and dephosphorylation; however the precise regulation of phosphorylation kinetics of Arpp19, an inhibitor of protein phosphatase 2A, is unclear. Here, the authors report that feedback between phosphorylation states of Ser67 and Ser109 of Arpp19 coordinates Arpp19-dependent inhibition of PP2A-B55 and Cyclin B activation during cell cycle progression.
url https://doi.org/10.1038/s41467-021-23657-0
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