Dapagliflozin reverses the imbalance of T helper 17 and T regulatory cells by inhibiting SGK1 in a mouse model of diabetic kidney disease

Dapagliflozin reverses the imbalance of T helper 17 and T regulatory cells by inhibiting SGK1 in a mouse model of diabetic kidney disease

An imbalance between T helper 17 (Th17) and T regulatory (Treg) cell subsets contributes to the pathogenesis of diabetic kidney disease (DKD). However, the underlying regulatory mechanisms that cause this imbalance are unknown. Serum/glucocorticoid‐regulated kinase 1 (SGK1) has been suggested to aff...

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Bibliographic Details
Main Authors: Dan Wang, Zikun Zhang, Zekun Si, Yanlin Yang, Shuangshuang Li, Yaoming Xue
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:FEBS Open Bio
Subjects:
diabetic kidney disease
inflammatory response
serum
glucocorticoid‐regulated kinase 1
sodium
glucose co‐transporter 2
Online Access:https://doi.org/10.1002/2211-5463.13147

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