Therapeutic Potential of Targeting Stromal Crosstalk-Mediated Immune Suppression in Pancreatic Cancer

Therapeutic Potential of Targeting Stromal Crosstalk-Mediated Immune Suppression in Pancreatic Cancer

The stroma-rich, immunosuppressive microenvironment is a hallmark of pancreatic ductal adenocarcinoma (PDA). Tumor cells and other cellular components of the tumor microenvironment, such as cancer associated fibroblasts, CD4+ T cells and myeloid cells, are linked by a web of interactions. Their cros...

Full description

Bibliographic Details
Main Authors: Wenting Du, Marina Pasca di Magliano, Yaqing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
tumor microenvironment
immune suppression
T cells
myeloid cells
cancer-associated fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.682217/full

Similar Items

Similar Items