Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications
Pancreatic cancer is one of the most aggressive human cancer types with a five-year survival less than 7%. Emerging evidence revealed that many genetic alterations in pancreatic cancer target epigenetic regulators. Some of these mutations are driver mutations in cancer development. Several most impo...
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doaj-4637f1b718ad4effa985ce49e95bf3de2020-11-24T23:16:40ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-12-011712213810.3390/ijms17122138ijms17122138Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical ImplicationsBrittany R. Silverman0Jiaqi Shi1Department of Pathology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USADepartment of Pathology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USAPancreatic cancer is one of the most aggressive human cancer types with a five-year survival less than 7%. Emerging evidence revealed that many genetic alterations in pancreatic cancer target epigenetic regulators. Some of these mutations are driver mutations in cancer development. Several most important mechanisms of epigenetic regulations include DNA methylation, histone modifications (methylation, acetylation, and ubiquitination), chromatin remodeling, and non-coding ribonucleic acids (RNAs). These modifications can alter chromatin structure and promoter accessibility, and thus lead to aberrant gene expression. However, exactly how these alterations affect epigenetic reprogramming in pancreatic cancer cells and in different stages of tumor development is still not clear. This mini-review summarizes the current knowledge of epigenetic alterations in pancreatic cancer development and progression, and discusses the clinical applications of epigenetic regulators as diagnostic biomarkers and therapeutic targets in pancreatic cancer.http://www.mdpi.com/1422-0067/17/12/2138genetic alterationsepigenetic regulatorspancreatic neoplasmspancreatic cancerclinical implication |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Brittany R. Silverman Jiaqi Shi |
spellingShingle |
Brittany R. Silverman Jiaqi Shi Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications International Journal of Molecular Sciences genetic alterations epigenetic regulators pancreatic neoplasms pancreatic cancer clinical implication |
author_facet |
Brittany R. Silverman Jiaqi Shi |
author_sort |
Brittany R. Silverman |
title |
Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications |
title_short |
Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications |
title_full |
Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications |
title_fullStr |
Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications |
title_full_unstemmed |
Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications |
title_sort |
alterations of epigenetic regulators in pancreatic cancer and their clinical implications |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2016-12-01 |
description |
Pancreatic cancer is one of the most aggressive human cancer types with a five-year survival less than 7%. Emerging evidence revealed that many genetic alterations in pancreatic cancer target epigenetic regulators. Some of these mutations are driver mutations in cancer development. Several most important mechanisms of epigenetic regulations include DNA methylation, histone modifications (methylation, acetylation, and ubiquitination), chromatin remodeling, and non-coding ribonucleic acids (RNAs). These modifications can alter chromatin structure and promoter accessibility, and thus lead to aberrant gene expression. However, exactly how these alterations affect epigenetic reprogramming in pancreatic cancer cells and in different stages of tumor development is still not clear. This mini-review summarizes the current knowledge of epigenetic alterations in pancreatic cancer development and progression, and discusses the clinical applications of epigenetic regulators as diagnostic biomarkers and therapeutic targets in pancreatic cancer. |
topic |
genetic alterations epigenetic regulators pancreatic neoplasms pancreatic cancer clinical implication |
url |
http://www.mdpi.com/1422-0067/17/12/2138 |
work_keys_str_mv |
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