Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Abstract Background DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed ‘epigenetic clocks’. The deviation of predicted age from the actual age (‘age acceleration residual’, AAR) has been reported to be associated with death. However, it is currently...

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Bibliographic Details
Main Authors: Qian Zhang, Costanza L. Vallerga, Rosie M. Walker, Tian Lin, Anjali K. Henders, Grant W. Montgomery, Ji He, Dongsheng Fan, Javed Fowdar, Martin Kennedy, Toni Pitcher, John Pearson, Glenda Halliday, John B. Kwok, Ian Hickie, Simon Lewis, Tim Anderson, Peter A. Silburn, George D. Mellick, Sarah E. Harris, Paul Redmond, Alison D. Murray, David J. Porteous, Christopher S. Haley, Kathryn L. Evans, Andrew M. McIntosh, Jian Yang, Jacob Gratten, Riccardo E. Marioni, Naomi R. Wray, Ian J. Deary, Allan F. McRae, Peter M. Visscher
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Genome Medicine
Subjects:
DNA methylation
Age prediction
Epigenetic clock
Ageing
Mortality
Online Access:http://link.springer.com/article/10.1186/s13073-019-0667-1

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