Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans. Their findings indicate a 60% heritability factor in British twins, and using a wide sample of Northern Europ...

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Main Authors: Joseph Dowsett, Egil Ferkingstad, Line Jee Hartmann Rasmussen, Lise Wegner Thørner, Magnús K. Magnússon, Karen Sugden, Gudmar Thorleifsson, Mike Frigge, Kristoffer Sølvsten Burgdorf, Sisse Rye Ostrowski, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Thomas Folkmann Hansen, Karina Banasik, Søren Brunak, DBDS Genomic Consortium, Vinicius Tragante, Sigrun Helga Lund, Lilja Stefansdottir, Bjarni Gunnarson, Richie Poulton, Louise Arseneault, Avshalom Caspi, Terrie E. Moffitt, Daníel Gudbjartsson, Jesper Eugen-Olsen, Hreinn Stefánsson, Kári Stefánsson, Henrik Ullum
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02144-8
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spelling doaj-463a8f996b614aa094ac078c66f08ee52021-06-06T11:30:53ZengNature Publishing GroupCommunications Biology2399-36422021-06-014111210.1038/s42003-021-02144-8Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptorJoseph Dowsett0Egil Ferkingstad1Line Jee Hartmann Rasmussen2Lise Wegner Thørner3Magnús K. Magnússon4Karen Sugden5Gudmar Thorleifsson6Mike Frigge7Kristoffer Sølvsten Burgdorf8Sisse Rye Ostrowski9Erik Sørensen10Christian Erikstrup11Ole Birger Pedersen12Thomas Folkmann Hansen13Karina Banasik14Søren Brunak15DBDS Genomic ConsortiumVinicius Tragante16Sigrun Helga Lund17Lilja Stefansdottir18Bjarni Gunnarson19Richie Poulton20Louise Arseneault21Avshalom Caspi22Terrie E. Moffitt23Daníel Gudbjartsson24Jesper Eugen-Olsen25Hreinn Stefánsson26Kári Stefánsson27Henrik Ullum28Department of Clinical Immunology, Copenhagen University HospitaldeCODE genetics/Amgen Inc.Department of Psychology and Neuroscience, Duke UniversityDepartment of Clinical Immunology, Copenhagen University HospitaldeCODE genetics/Amgen Inc.Department of Psychology and Neuroscience, Duke UniversitydeCODE genetics/Amgen Inc.deCODE genetics/Amgen Inc.Department of Clinical Immunology, Copenhagen University HospitalDepartment of Clinical Immunology, Copenhagen University HospitalDepartment of Clinical Immunology, Copenhagen University HospitalDepartment of Immunology, Aarhus University HospitalDepartment of Immunology, Naestved HospitalDanish Headache Center, Copenhagen University Hospital, Rigshospitalet GlostrupNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of CopenhagenNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of CopenhagendeCODE genetics/Amgen Inc.deCODE genetics/Amgen Inc.deCODE genetics/Amgen Inc.deCODE genetics/Amgen Inc.Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of OtagoSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King’s College LondonDepartment of Psychology and Neuroscience, Duke UniversityDepartment of Psychology and Neuroscience, Duke UniversitydeCODE genetics/Amgen Inc.Department of Clinical Research, Copenhagen University Hospital Amager and HvidovredeCODE genetics/Amgen Inc.deCODE genetics/Amgen Inc.Department of Clinical Immunology, Copenhagen University HospitalDowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans. Their findings indicate a 60% heritability factor in British twins, and using a wide sample of Northern European genome samples they identify eleven genetic loci associated with an increase or decrease of this chronic inflammation marker.https://doi.org/10.1038/s42003-021-02144-8
collection DOAJ
language English
format Article
sources DOAJ
author Joseph Dowsett
Egil Ferkingstad
Line Jee Hartmann Rasmussen
Lise Wegner Thørner
Magnús K. Magnússon
Karen Sugden
Gudmar Thorleifsson
Mike Frigge
Kristoffer Sølvsten Burgdorf
Sisse Rye Ostrowski
Erik Sørensen
Christian Erikstrup
Ole Birger Pedersen
Thomas Folkmann Hansen
Karina Banasik
Søren Brunak
DBDS Genomic Consortium
Vinicius Tragante
Sigrun Helga Lund
Lilja Stefansdottir
Bjarni Gunnarson
Richie Poulton
Louise Arseneault
Avshalom Caspi
Terrie E. Moffitt
Daníel Gudbjartsson
Jesper Eugen-Olsen
Hreinn Stefánsson
Kári Stefánsson
Henrik Ullum
spellingShingle Joseph Dowsett
Egil Ferkingstad
Line Jee Hartmann Rasmussen
Lise Wegner Thørner
Magnús K. Magnússon
Karen Sugden
Gudmar Thorleifsson
Mike Frigge
Kristoffer Sølvsten Burgdorf
Sisse Rye Ostrowski
Erik Sørensen
Christian Erikstrup
Ole Birger Pedersen
Thomas Folkmann Hansen
Karina Banasik
Søren Brunak
DBDS Genomic Consortium
Vinicius Tragante
Sigrun Helga Lund
Lilja Stefansdottir
Bjarni Gunnarson
Richie Poulton
Louise Arseneault
Avshalom Caspi
Terrie E. Moffitt
Daníel Gudbjartsson
Jesper Eugen-Olsen
Hreinn Stefánsson
Kári Stefánsson
Henrik Ullum
Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor
Communications Biology
author_facet Joseph Dowsett
Egil Ferkingstad
Line Jee Hartmann Rasmussen
Lise Wegner Thørner
Magnús K. Magnússon
Karen Sugden
Gudmar Thorleifsson
Mike Frigge
Kristoffer Sølvsten Burgdorf
Sisse Rye Ostrowski
Erik Sørensen
Christian Erikstrup
Ole Birger Pedersen
Thomas Folkmann Hansen
Karina Banasik
Søren Brunak
DBDS Genomic Consortium
Vinicius Tragante
Sigrun Helga Lund
Lilja Stefansdottir
Bjarni Gunnarson
Richie Poulton
Louise Arseneault
Avshalom Caspi
Terrie E. Moffitt
Daníel Gudbjartsson
Jesper Eugen-Olsen
Hreinn Stefánsson
Kári Stefánsson
Henrik Ullum
author_sort Joseph Dowsett
title Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor
title_short Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor
title_full Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor
title_fullStr Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor
title_full_unstemmed Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor
title_sort eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-06-01
description Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans. Their findings indicate a 60% heritability factor in British twins, and using a wide sample of Northern European genome samples they identify eleven genetic loci associated with an increase or decrease of this chronic inflammation marker.
url https://doi.org/10.1038/s42003-021-02144-8
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