Spirometry and volumetric capnography in lung function assessment of obese and normal‐weight individuals without asthma

Objective: To analyze and compare lung function of obese and healthy, normal‐weight children and adolescents, without asthma, through spirometry and volumetric capnography. Methods: Cross‐sectional study including 77 subjects (38 obese) aged 5–17 years. All subjects underwent spirometry and volumetr...

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Main Authors: Mariana S. Ferreira, Roberto T. Mendes, Fernando A.L. Marson, Mariana P. Zambon, Maria A.R.G.M. Antonio, Ilma A. Paschoal, Adyléia A.D.C. Toro, Silvana D. Severino, Maria A.G.O. Ribeiro, José D. Ribeiro
Format: Article
Language:Portuguese
Published: Elsevier 2017-07-01
Series:Jornal de Pediatria (Versão em Português)
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2255553617300484
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spelling doaj-463bac48604b4200aff023dea60c63dc2020-11-24T23:48:05ZporElsevierJornal de Pediatria (Versão em Português)2255-55362017-07-0193439840510.1016/j.jpedp.2017.04.005Spirometry and volumetric capnography in lung function assessment of obese and normal‐weight individuals without asthmaMariana S. Ferreira0Roberto T. Mendes1Fernando A.L. Marson2Mariana P. Zambon3Maria A.R.G.M. Antonio4Ilma A. Paschoal5Adyléia A.D.C. Toro6Silvana D. Severino7Maria A.G.O. Ribeiro8José D. Ribeiro9Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrasilUniversidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrasilUniversidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrasilUniversidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrasilUniversidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrasilUniversidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Clínica Médica, Campinas, SP, BrasilUniversidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrasilUniversidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrasilUniversidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrasilUniversidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, BrasilObjective: To analyze and compare lung function of obese and healthy, normal‐weight children and adolescents, without asthma, through spirometry and volumetric capnography. Methods: Cross‐sectional study including 77 subjects (38 obese) aged 5–17 years. All subjects underwent spirometry and volumetric capnography. The evaluations were repeated in obese subjects after the use of a bronchodilator. Results: At the spirometry assessment, obese individuals, when compared with the control group, showed lower values of forced expiratory volume in the first second by forced vital capacity (FEV1/FVC) and expiratory flows at 75% and between 25 and 75% of the FVC (p < 0.05). Volumetric capnography showed that obese individuals had a higher volume of produced carbon dioxide and alveolar tidal volume (p < 0.05). Additionally, the associations between dead space volume and tidal volume, as well as phase‐3 slope normalized by tidal volume, were lower in healthy subjects (p < 0.05). These data suggest that obesity does not alter ventilation homogeneity, but flow homogeneity. After subdividing the groups by age, a greater difference in lung function was observed in obese and healthy individuals aged >11 years (p < 0.05). Conclusion: Even without the diagnosis of asthma by clinical criteria and without response to bronchodilator use, obese individuals showed lower FEV1/FVC values and forced expiratory flow, indicating the presence of an obstructive process. Volumetric capnography showed that obese individuals had higher alveolar tidal volume, with no alterations in ventilation homogeneity, suggesting flow alterations, without affecting lung volumes.http://www.sciencedirect.com/science/article/pii/S2255553617300484CapnographySpirometryObesity
collection DOAJ
language Portuguese
format Article
sources DOAJ
author Mariana S. Ferreira
Roberto T. Mendes
Fernando A.L. Marson
Mariana P. Zambon
Maria A.R.G.M. Antonio
Ilma A. Paschoal
Adyléia A.D.C. Toro
Silvana D. Severino
Maria A.G.O. Ribeiro
José D. Ribeiro
spellingShingle Mariana S. Ferreira
Roberto T. Mendes
Fernando A.L. Marson
Mariana P. Zambon
Maria A.R.G.M. Antonio
Ilma A. Paschoal
Adyléia A.D.C. Toro
Silvana D. Severino
Maria A.G.O. Ribeiro
José D. Ribeiro
Spirometry and volumetric capnography in lung function assessment of obese and normal‐weight individuals without asthma
Jornal de Pediatria (Versão em Português)
Capnography
Spirometry
Obesity
author_facet Mariana S. Ferreira
Roberto T. Mendes
Fernando A.L. Marson
Mariana P. Zambon
Maria A.R.G.M. Antonio
Ilma A. Paschoal
Adyléia A.D.C. Toro
Silvana D. Severino
Maria A.G.O. Ribeiro
José D. Ribeiro
author_sort Mariana S. Ferreira
title Spirometry and volumetric capnography in lung function assessment of obese and normal‐weight individuals without asthma
title_short Spirometry and volumetric capnography in lung function assessment of obese and normal‐weight individuals without asthma
title_full Spirometry and volumetric capnography in lung function assessment of obese and normal‐weight individuals without asthma
title_fullStr Spirometry and volumetric capnography in lung function assessment of obese and normal‐weight individuals without asthma
title_full_unstemmed Spirometry and volumetric capnography in lung function assessment of obese and normal‐weight individuals without asthma
title_sort spirometry and volumetric capnography in lung function assessment of obese and normal‐weight individuals without asthma
publisher Elsevier
series Jornal de Pediatria (Versão em Português)
issn 2255-5536
publishDate 2017-07-01
description Objective: To analyze and compare lung function of obese and healthy, normal‐weight children and adolescents, without asthma, through spirometry and volumetric capnography. Methods: Cross‐sectional study including 77 subjects (38 obese) aged 5–17 years. All subjects underwent spirometry and volumetric capnography. The evaluations were repeated in obese subjects after the use of a bronchodilator. Results: At the spirometry assessment, obese individuals, when compared with the control group, showed lower values of forced expiratory volume in the first second by forced vital capacity (FEV1/FVC) and expiratory flows at 75% and between 25 and 75% of the FVC (p < 0.05). Volumetric capnography showed that obese individuals had a higher volume of produced carbon dioxide and alveolar tidal volume (p < 0.05). Additionally, the associations between dead space volume and tidal volume, as well as phase‐3 slope normalized by tidal volume, were lower in healthy subjects (p < 0.05). These data suggest that obesity does not alter ventilation homogeneity, but flow homogeneity. After subdividing the groups by age, a greater difference in lung function was observed in obese and healthy individuals aged >11 years (p < 0.05). Conclusion: Even without the diagnosis of asthma by clinical criteria and without response to bronchodilator use, obese individuals showed lower FEV1/FVC values and forced expiratory flow, indicating the presence of an obstructive process. Volumetric capnography showed that obese individuals had higher alveolar tidal volume, with no alterations in ventilation homogeneity, suggesting flow alterations, without affecting lung volumes.
topic Capnography
Spirometry
Obesity
url http://www.sciencedirect.com/science/article/pii/S2255553617300484
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