Reduction of spleen size in a child with Hyperreactive Malarious Splenomegaly (HMS) treated outside the Brazilian endemic area of malaria with only one course of quinine

• Main Authors: Maria Imaculada Muniz-Junqueira, Mário A. P. Moraes, Philip Davis Marsden
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1992-12-01
• Series: Revista da Sociedade Brasileira de Medicina Tropical
• Subjects: Esplenomegalia hiperreativa da malária; Malária crônica; Tratamento curativo antimalárico
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821992000400008&lng=en&tlng=en

We report the clinical picture, treatment and evolution of a child with hyperreactive malarious splenomegaly treated outside the endemic area of malaria. The patient presented gross splenomegaly, proceeded from an area where malaria is endemic, showed increased immunoglobulins levels, high antimalarial antibody titres and hepatic sinusoidal lymphocytosis. The child did not return to an area where malaria is endemic and showed a favorable response to only one course of quinine. The response of this patient to limited antimalarial therapy suggests the importance of reinfection with malaria in the development and maintenance of this syndrome.