Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansion
We investigated the ability of patients with myotonic dystrophy type 1 to recognise basic facial emotions. We also explored the relationship between facial emotion recognition, neuropsychological data, personality, and CTG repeat expansion data in the DM-1 group. In total, 50 patients with DM-1 (28...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
LED Edizioni Universitarie
2009-04-01
|
Series: | Neuropsychological Trends |
Subjects: | |
Online Access: | http://www.ledonline.it/NeuropsychologicalTrends/allegati/NeuropsychologicalTrends_5_Winblad.pdf |
id |
doaj-463df92493d94754879ce69b1d6b309e |
---|---|
record_format |
Article |
spelling |
doaj-463df92493d94754879ce69b1d6b309e2020-11-24T21:04:48ZengLED Edizioni Universitarie Neuropsychological Trends1970-321X1970-32012009-04-0154357Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansionStefan Winblad0Pauls Hellström1Christopher Lindberg2Stefan Hansen3Department of Psychology, Göteborg University, Göteborg, Sweden; Neuromuscular Center, Department of Neurology, Sahlgrenska University Hospital, Mölndal, Sweden; Unit for Neuropsychology and Neuropsychiatry, Department of Neurology, Sahlgrenska University Hospital, Göteborg, SwedenUnit for Neuropsychology and Neuropsychiatry, Department of Neurology, Sahlgrenska University Hospital, Göteborg, SwedenInstitute of Clinical Neuroscience, Sahlgrenska Academy, Göteborg, Sweden; Neuromuscular Center, Department of Neurology, Sahlgrenska University Hospital, Mölndal, SwedenDepartment of Psychology, Göteborg University, Göteborg, SwedenWe investigated the ability of patients with myotonic dystrophy type 1 to recognise basic facial emotions. We also explored the relationship between facial emotion recognition, neuropsychological data, personality, and CTG repeat expansion data in the DM-1 group. In total, 50 patients with DM-1 (28 women and 22 men) participated, with 41 healthy controls. Recognition of facial emotional expressions was assessed using photographs of basic emotions. A set of tests measured cognition and personality dimensions, and CTG repeat size was quantified in blood lymphocytes. Patients with DM-1 showed impaired recognition of facial emotions compared with controls. A significant negative correlation was found between total score of emotion recognition in a forced choice task and CTG repeat size. Furthermore, specific cognitive functions (vocabulary, visuospatial construction ability, and speed) and personality dimensions (reward dependence and cooperativeness) correlated with scores on the forced choice emotion recognition task.These findings revealed a CTG repeat dependent facial emotion recognition deficit in the DM-1 group, which was associated with specific neuropsychological functions. Furthermore, a correlation was found between facial emotional recognition ability and personality dimensions associated with sociability. This adds a new clinically relevant dimension in the cognitive deficits associated with DM-1. http://www.ledonline.it/NeuropsychologicalTrends/allegati/NeuropsychologicalTrends_5_Winblad.pdfMyotonic dystrophyEmotion recognitionCTG repeat expansionNeuropsychologyPersonality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefan Winblad Pauls Hellström Christopher Lindberg Stefan Hansen |
spellingShingle |
Stefan Winblad Pauls Hellström Christopher Lindberg Stefan Hansen Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansion Neuropsychological Trends Myotonic dystrophy Emotion recognition CTG repeat expansion Neuropsychology Personality |
author_facet |
Stefan Winblad Pauls Hellström Christopher Lindberg Stefan Hansen |
author_sort |
Stefan Winblad |
title |
Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansion |
title_short |
Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansion |
title_full |
Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansion |
title_fullStr |
Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansion |
title_full_unstemmed |
Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansion |
title_sort |
facial emotion recognition in myotonic dystrophy type 1 correlates with ctg repeat expansion |
publisher |
LED Edizioni Universitarie |
series |
Neuropsychological Trends |
issn |
1970-321X 1970-3201 |
publishDate |
2009-04-01 |
description |
We investigated the ability of patients with myotonic dystrophy type 1 to recognise basic facial emotions. We also explored the relationship between facial emotion recognition, neuropsychological data, personality, and CTG repeat expansion data in the DM-1 group. In total, 50 patients with DM-1 (28 women and 22 men) participated, with 41 healthy controls. Recognition of facial emotional expressions was assessed using photographs of basic emotions. A set of tests measured cognition and personality dimensions, and CTG repeat size was quantified in blood lymphocytes. Patients with DM-1 showed impaired recognition of facial emotions compared with controls. A significant negative correlation was found between total score of emotion recognition in a forced choice task and CTG repeat size. Furthermore, specific cognitive functions (vocabulary, visuospatial construction ability, and speed) and personality dimensions (reward dependence and cooperativeness) correlated with scores on the forced choice emotion recognition task.These findings revealed a CTG repeat dependent facial emotion recognition deficit in the DM-1 group, which was associated with specific neuropsychological functions. Furthermore, a correlation was found between facial emotional recognition ability and personality dimensions associated with sociability. This adds a new clinically relevant dimension in the cognitive deficits associated with DM-1. |
topic |
Myotonic dystrophy Emotion recognition CTG repeat expansion Neuropsychology Personality |
url |
http://www.ledonline.it/NeuropsychologicalTrends/allegati/NeuropsychologicalTrends_5_Winblad.pdf |
work_keys_str_mv |
AT stefanwinblad facialemotionrecognitioninmyotonicdystrophytype1correlateswithctgrepeatexpansion AT paulshellstrom facialemotionrecognitioninmyotonicdystrophytype1correlateswithctgrepeatexpansion AT christopherlindberg facialemotionrecognitioninmyotonicdystrophytype1correlateswithctgrepeatexpansion AT stefanhansen facialemotionrecognitioninmyotonicdystrophytype1correlateswithctgrepeatexpansion |
_version_ |
1716769696541310976 |