Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause
A variety of U.S. Food and Drug Administration-approved hormone therapy options are currently used to successfully alleviate unwanted symptoms associated with the changing endogenous hormonal milieu that occurs in midlife with menopause. Depending on the primary indication for treatment, different h...
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Frontiers Media S.A.
2021-07-01
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Series: | Frontiers in Behavioral Neuroscience |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.696838/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stephanie V. Koebele Stephanie V. Koebele Ryoko Hiroi Ryoko Hiroi Zachary M. T. Plumley Zachary M. T. Plumley Ryan Melikian Ryan Melikian Alesia V. Prakapenka Alesia V. Prakapenka Shruti Patel Shruti Patel Catherine Carson Catherine Carson Destiney Kirby Destiney Kirby Sarah E. Mennenga Sarah E. Mennenga Loretta P. Mayer Cheryl A. Dyer Heather A. Bimonte-Nelson Heather A. Bimonte-Nelson |
spellingShingle |
Stephanie V. Koebele Stephanie V. Koebele Ryoko Hiroi Ryoko Hiroi Zachary M. T. Plumley Zachary M. T. Plumley Ryan Melikian Ryan Melikian Alesia V. Prakapenka Alesia V. Prakapenka Shruti Patel Shruti Patel Catherine Carson Catherine Carson Destiney Kirby Destiney Kirby Sarah E. Mennenga Sarah E. Mennenga Loretta P. Mayer Cheryl A. Dyer Heather A. Bimonte-Nelson Heather A. Bimonte-Nelson Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause Frontiers in Behavioral Neuroscience VCD menopause estrogen progesterone levonorgestrel memory |
author_facet |
Stephanie V. Koebele Stephanie V. Koebele Ryoko Hiroi Ryoko Hiroi Zachary M. T. Plumley Zachary M. T. Plumley Ryan Melikian Ryan Melikian Alesia V. Prakapenka Alesia V. Prakapenka Shruti Patel Shruti Patel Catherine Carson Catherine Carson Destiney Kirby Destiney Kirby Sarah E. Mennenga Sarah E. Mennenga Loretta P. Mayer Cheryl A. Dyer Heather A. Bimonte-Nelson Heather A. Bimonte-Nelson |
author_sort |
Stephanie V. Koebele |
title |
Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause |
title_short |
Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause |
title_full |
Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause |
title_fullStr |
Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause |
title_full_unstemmed |
Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause |
title_sort |
clinically used hormone formulations differentially impact memory, anxiety-like, and depressive-like behaviors in a rat model of transitional menopause |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2021-07-01 |
description |
A variety of U.S. Food and Drug Administration-approved hormone therapy options are currently used to successfully alleviate unwanted symptoms associated with the changing endogenous hormonal milieu that occurs in midlife with menopause. Depending on the primary indication for treatment, different hormone therapy formulations are utilized, including estrogen-only, progestogen-only, or combined estrogen plus progestogen options. There is little known about how these formulations, or their unique pharmacodynamics, impact neurobiological processes. Seemingly disparate pre-clinical and clinical findings regarding the cognitive effects of hormone therapies, such as the negative effects associated with conjugated equine estrogens and medroxyprogesterone acetate vs. naturally circulating 17β-estradiol (E2) and progesterone, signal a critical need to further investigate the neuro-cognitive impact of hormone therapy formulations. Here, utilizing a rat model of transitional menopause, we administered either E2, progesterone, levonorgestrel, or combinations of E2 with progesterone or with levonorgestrel daily to follicle-depleted, middle-aged rats. A battery of assessments, including spatial memory, anxiety-like behaviors, and depressive-like behaviors, as well as endocrine status and ovarian follicle complement, were evaluated. Results indicate divergent outcomes for memory, anxiety, and depression, as well as unique physiological profiles, that were dependent upon the hormone regimen administered. Overall, the combination hormone treatments had the most consistently favorable profile for the domains evaluated in rats that had undergone experimentally induced transitional menopause and remained ovary-intact. The collective results underscore the importance of investigating variations in hormone therapy formulation as well as the menopause background upon which these formulations are delivered. |
topic |
VCD menopause estrogen progesterone levonorgestrel memory |
url |
https://www.frontiersin.org/articles/10.3389/fnbeh.2021.696838/full |
work_keys_str_mv |
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doaj-464313416c5640e38d944c0eb4ee42932021-07-21T14:16:14ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532021-07-011510.3389/fnbeh.2021.696838696838Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional MenopauseStephanie V. Koebele0Stephanie V. Koebele1Ryoko Hiroi2Ryoko Hiroi3Zachary M. T. Plumley4Zachary M. T. Plumley5Ryan Melikian6Ryan Melikian7Alesia V. Prakapenka8Alesia V. Prakapenka9Shruti Patel10Shruti Patel11Catherine Carson12Catherine Carson13Destiney Kirby14Destiney Kirby15Sarah E. Mennenga16Sarah E. Mennenga17Loretta P. Mayer18Cheryl A. Dyer19Heather A. Bimonte-Nelson20Heather A. Bimonte-Nelson21Department of Psychology, Arizona State University, Tempe, AZ, United StatesArizona Alzheimer’s Consortium, Phoenix, AZ, United StatesDepartment of Psychology, Arizona State University, Tempe, AZ, United StatesArizona Alzheimer’s Consortium, Phoenix, AZ, United StatesDepartment of Psychology, Arizona State University, Tempe, AZ, United StatesArizona Alzheimer’s Consortium, Phoenix, AZ, United StatesDepartment of Psychology, Arizona State University, Tempe, AZ, United StatesArizona Alzheimer’s Consortium, Phoenix, AZ, United StatesDepartment of Psychology, Arizona State University, Tempe, AZ, United StatesArizona Alzheimer’s Consortium, Phoenix, AZ, United StatesDepartment of Psychology, Arizona State University, Tempe, AZ, United StatesArizona Alzheimer’s Consortium, Phoenix, AZ, United StatesDepartment of Psychology, Arizona State University, Tempe, AZ, United StatesArizona Alzheimer’s Consortium, Phoenix, AZ, United StatesDepartment of Psychology, Arizona State University, Tempe, AZ, United StatesArizona Alzheimer’s Consortium, Phoenix, AZ, United StatesDepartment of Psychology, Arizona State University, Tempe, AZ, United StatesArizona Alzheimer’s Consortium, Phoenix, AZ, United StatesFYXX Foundation, Flagstaff, AZ, United StatesFYXX Foundation, Flagstaff, AZ, United StatesDepartment of Psychology, Arizona State University, Tempe, AZ, United StatesArizona Alzheimer’s Consortium, Phoenix, AZ, United StatesA variety of U.S. Food and Drug Administration-approved hormone therapy options are currently used to successfully alleviate unwanted symptoms associated with the changing endogenous hormonal milieu that occurs in midlife with menopause. Depending on the primary indication for treatment, different hormone therapy formulations are utilized, including estrogen-only, progestogen-only, or combined estrogen plus progestogen options. There is little known about how these formulations, or their unique pharmacodynamics, impact neurobiological processes. Seemingly disparate pre-clinical and clinical findings regarding the cognitive effects of hormone therapies, such as the negative effects associated with conjugated equine estrogens and medroxyprogesterone acetate vs. naturally circulating 17β-estradiol (E2) and progesterone, signal a critical need to further investigate the neuro-cognitive impact of hormone therapy formulations. Here, utilizing a rat model of transitional menopause, we administered either E2, progesterone, levonorgestrel, or combinations of E2 with progesterone or with levonorgestrel daily to follicle-depleted, middle-aged rats. A battery of assessments, including spatial memory, anxiety-like behaviors, and depressive-like behaviors, as well as endocrine status and ovarian follicle complement, were evaluated. Results indicate divergent outcomes for memory, anxiety, and depression, as well as unique physiological profiles, that were dependent upon the hormone regimen administered. Overall, the combination hormone treatments had the most consistently favorable profile for the domains evaluated in rats that had undergone experimentally induced transitional menopause and remained ovary-intact. The collective results underscore the importance of investigating variations in hormone therapy formulation as well as the menopause background upon which these formulations are delivered.https://www.frontiersin.org/articles/10.3389/fnbeh.2021.696838/fullVCDmenopauseestrogenprogesteronelevonorgestrelmemory |