DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment
Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by genomic instability. MM cells present various forms of genetic instability, including chromosomal instability, microsatellite instability, and base-pair alterations, as well as changes in chromosome number. The tumor micro...
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doaj-46512b133e98474ba98c3e9989a29b4b2021-01-29T00:08:05ZengMDPI AGCancers2072-66942021-01-011350450410.3390/cancers13030504DNA Damage Response in Multiple Myeloma: The Role of the Tumor MicroenvironmentTakayuki Saitoh0Tsukasa Oda1Department of Laboratory Sciences, Graduate School of Health Sciences, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, JapanLaboratory of Molecular Genetics, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8512, JapanMultiple myeloma (MM) is an incurable plasma cell malignancy characterized by genomic instability. MM cells present various forms of genetic instability, including chromosomal instability, microsatellite instability, and base-pair alterations, as well as changes in chromosome number. The tumor microenvironment and an abnormal DNA repair function affect genetic instability in this disease. In addition, states of the tumor microenvironment itself, such as inflammation and hypoxia, influence the DNA damage response, which includes DNA repair mechanisms, cell cycle checkpoints, and apoptotic pathways. Unrepaired DNA damage in tumor cells has been shown to exacerbate genomic instability and aberrant features that enable MM progression and drug resistance. This review provides an overview of the DNA repair pathways, with a special focus on their function in MM, and discusses the role of the tumor microenvironment in governing DNA repair mechanisms.https://www.mdpi.com/2072-6694/13/3/504multiple myelomaDNA repairgenomic instabilityDNA damage responsebase excision repairhomologous recombination |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takayuki Saitoh Tsukasa Oda |
spellingShingle |
Takayuki Saitoh Tsukasa Oda DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment Cancers multiple myeloma DNA repair genomic instability DNA damage response base excision repair homologous recombination |
author_facet |
Takayuki Saitoh Tsukasa Oda |
author_sort |
Takayuki Saitoh |
title |
DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment |
title_short |
DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment |
title_full |
DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment |
title_fullStr |
DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment |
title_full_unstemmed |
DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment |
title_sort |
dna damage response in multiple myeloma: the role of the tumor microenvironment |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-01-01 |
description |
Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by genomic instability. MM cells present various forms of genetic instability, including chromosomal instability, microsatellite instability, and base-pair alterations, as well as changes in chromosome number. The tumor microenvironment and an abnormal DNA repair function affect genetic instability in this disease. In addition, states of the tumor microenvironment itself, such as inflammation and hypoxia, influence the DNA damage response, which includes DNA repair mechanisms, cell cycle checkpoints, and apoptotic pathways. Unrepaired DNA damage in tumor cells has been shown to exacerbate genomic instability and aberrant features that enable MM progression and drug resistance. This review provides an overview of the DNA repair pathways, with a special focus on their function in MM, and discusses the role of the tumor microenvironment in governing DNA repair mechanisms. |
topic |
multiple myeloma DNA repair genomic instability DNA damage response base excision repair homologous recombination |
url |
https://www.mdpi.com/2072-6694/13/3/504 |
work_keys_str_mv |
AT takayukisaitoh dnadamageresponseinmultiplemyelomatheroleofthetumormicroenvironment AT tsukasaoda dnadamageresponseinmultiplemyelomatheroleofthetumormicroenvironment |
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