TRIP6 functions in brain ciliogenesis

TRIP6 functions in brain ciliogenesis

Cilia, tiny outgrowths of cells, are essential for life. Here, the author’s describe the scaffold protein TRIP6, which promotes the assembly of ciliary proteins required for ciliogenesis, and show that its absence results in hydrocephalus.

Bibliographic Details
Main Authors: Shalmali Shukla, Ronny Haenold, Pavel Urbánek, Lucien Frappart, Shamci Monajembashi, Paulius Grigaravicius, Sigrun Nagel, Woo Kee Min, Alicia Tapias, Olivier Kassel, Heike Heuer, Zhao-Qi Wang, Aspasia Ploubidou, Peter Herrlich
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26057-6
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spelling doaj-4652349346cd445aaa9dd98d427526362021-10-10T11:45:47ZengNature Publishing GroupNature Communications2041-17232021-10-0112111610.1038/s41467-021-26057-6TRIP6 functions in brain ciliogenesisShalmali Shukla0Ronny Haenold1Pavel Urbánek2Lucien Frappart3Shamci Monajembashi4Paulius Grigaravicius5Sigrun Nagel6Woo Kee Min7Alicia Tapias8Olivier Kassel9Heike Heuer10Zhao-Qi Wang11Aspasia Ploubidou12Peter Herrlich13Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)Karlsruhe Institute of Technology (KIT), Institute for Biological and Chemical Systems-Biological Information Processing (IBCS-BIP)Department of Endocrinology, University of Duisburg-EssenLeibniz Institute on Aging – Fritz Lipmann Institute (FLI)Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)Cilia, tiny outgrowths of cells, are essential for life. Here, the author’s describe the scaffold protein TRIP6, which promotes the assembly of ciliary proteins required for ciliogenesis, and show that its absence results in hydrocephalus.https://doi.org/10.1038/s41467-021-26057-6
collection DOAJ
language English
format Article
sources DOAJ
author Shalmali Shukla
Ronny Haenold
Pavel Urbánek
Lucien Frappart
Shamci Monajembashi
Paulius Grigaravicius
Sigrun Nagel
Woo Kee Min
Alicia Tapias
Olivier Kassel
Heike Heuer
Zhao-Qi Wang
Aspasia Ploubidou
Peter Herrlich
spellingShingle Shalmali Shukla
Ronny Haenold
Pavel Urbánek
Lucien Frappart
Shamci Monajembashi
Paulius Grigaravicius
Sigrun Nagel
Woo Kee Min
Alicia Tapias
Olivier Kassel
Heike Heuer
Zhao-Qi Wang
Aspasia Ploubidou
Peter Herrlich
TRIP6 functions in brain ciliogenesis
Nature Communications
author_facet Shalmali Shukla
Ronny Haenold
Pavel Urbánek
Lucien Frappart
Shamci Monajembashi
Paulius Grigaravicius
Sigrun Nagel
Woo Kee Min
Alicia Tapias
Olivier Kassel
Heike Heuer
Zhao-Qi Wang
Aspasia Ploubidou
Peter Herrlich
author_sort Shalmali Shukla
title TRIP6 functions in brain ciliogenesis
title_short TRIP6 functions in brain ciliogenesis
title_full TRIP6 functions in brain ciliogenesis
title_fullStr TRIP6 functions in brain ciliogenesis
title_full_unstemmed TRIP6 functions in brain ciliogenesis
title_sort trip6 functions in brain ciliogenesis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-10-01
description Cilia, tiny outgrowths of cells, are essential for life. Here, the author’s describe the scaffold protein TRIP6, which promotes the assembly of ciliary proteins required for ciliogenesis, and show that its absence results in hydrocephalus.
url https://doi.org/10.1038/s41467-021-26057-6
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