Ultrasonic image analysis of longitudinal strain in uremic patients with preserved left ventricular ejection fraction
Abstract Background Patients with uremia have high cardiovascular disease morbidity and mortality despite having normal left ventricular ejection fraction (LVEF). Longitudinal strain (LS) can be associated with subtle changes in LV systolic function. The aim of this study was to use two-dimensional...
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doaj-4656a684c3724fd9bf620b6ba3b26ce42020-11-25T01:41:07ZengBMCBioMedical Engineering OnLine1475-925X2018-08-0117111110.1186/s12938-018-0536-yUltrasonic image analysis of longitudinal strain in uremic patients with preserved left ventricular ejection fractionYuqin Ma0Bo Zhang1Yuzhen Zhang2Yun Dong3Ruiqing Zhang4Department of Ultrasound in Medicine, Shanghai East Hospital, Tongji University, School of MedicineDepartment of Ultrasound in Medicine, Shanghai East Hospital, Tongji University, School of MedicineKey Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of MedicineDepartment of Ultrasound in Medicine, Shanghai East Hospital, Tongji University, School of MedicineDepartment of Nephrology, Shanghai East Hospital, Tongji University, School of MedicineAbstract Background Patients with uremia have high cardiovascular disease morbidity and mortality despite having normal left ventricular ejection fraction (LVEF). Longitudinal strain (LS) can be associated with subtle changes in LV systolic function. The aim of this study was to use two-dimensional speckle-tracking echocardiography (2DSTE) to assess subclinical LV myocardial dysfunction and to explore strain-changing regularities in uremic patients with LVEF ≥ 55%. Methods The study population included 40 uremic patients and 40 healthy volunteers. 2DSTE was performed on all participants to assess peak LS in the basal, mid and apical LV (BLS, MLS and ALS) and the respective time to peak LS (T-BLS, T-MLS, T-ALS). Results BLS, MLS, and ALS were significantly decreased in the uremic group relative to healthy controls and LS increased going in a basal to apical direction in both groups. T-BLS, T-MLS and T-ALS was significantly increased in the uremic group compared with the control group. In uremic patients, T-BLS, but not T-MLS or T-ALS, was significantly delayed relative to the control group. Bivariate analysis of creatinine (Cr) or urea nitrogen and strain parameters revealed a correlation only between ALS and Cr. Conclusion 2DSTE can identify LV myocardial abnormalities in uremic patients with preserved LVEF at early stage, as well as some changing regularities of LS and T-LS in the left ventricle.http://link.springer.com/article/10.1186/s12938-018-0536-ySpeckle tracking echocardiographyVentricular function, leftStrainUremiaRenal dialysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuqin Ma Bo Zhang Yuzhen Zhang Yun Dong Ruiqing Zhang |
spellingShingle |
Yuqin Ma Bo Zhang Yuzhen Zhang Yun Dong Ruiqing Zhang Ultrasonic image analysis of longitudinal strain in uremic patients with preserved left ventricular ejection fraction BioMedical Engineering OnLine Speckle tracking echocardiography Ventricular function, left Strain Uremia Renal dialysis |
author_facet |
Yuqin Ma Bo Zhang Yuzhen Zhang Yun Dong Ruiqing Zhang |
author_sort |
Yuqin Ma |
title |
Ultrasonic image analysis of longitudinal strain in uremic patients with preserved left ventricular ejection fraction |
title_short |
Ultrasonic image analysis of longitudinal strain in uremic patients with preserved left ventricular ejection fraction |
title_full |
Ultrasonic image analysis of longitudinal strain in uremic patients with preserved left ventricular ejection fraction |
title_fullStr |
Ultrasonic image analysis of longitudinal strain in uremic patients with preserved left ventricular ejection fraction |
title_full_unstemmed |
Ultrasonic image analysis of longitudinal strain in uremic patients with preserved left ventricular ejection fraction |
title_sort |
ultrasonic image analysis of longitudinal strain in uremic patients with preserved left ventricular ejection fraction |
publisher |
BMC |
series |
BioMedical Engineering OnLine |
issn |
1475-925X |
publishDate |
2018-08-01 |
description |
Abstract Background Patients with uremia have high cardiovascular disease morbidity and mortality despite having normal left ventricular ejection fraction (LVEF). Longitudinal strain (LS) can be associated with subtle changes in LV systolic function. The aim of this study was to use two-dimensional speckle-tracking echocardiography (2DSTE) to assess subclinical LV myocardial dysfunction and to explore strain-changing regularities in uremic patients with LVEF ≥ 55%. Methods The study population included 40 uremic patients and 40 healthy volunteers. 2DSTE was performed on all participants to assess peak LS in the basal, mid and apical LV (BLS, MLS and ALS) and the respective time to peak LS (T-BLS, T-MLS, T-ALS). Results BLS, MLS, and ALS were significantly decreased in the uremic group relative to healthy controls and LS increased going in a basal to apical direction in both groups. T-BLS, T-MLS and T-ALS was significantly increased in the uremic group compared with the control group. In uremic patients, T-BLS, but not T-MLS or T-ALS, was significantly delayed relative to the control group. Bivariate analysis of creatinine (Cr) or urea nitrogen and strain parameters revealed a correlation only between ALS and Cr. Conclusion 2DSTE can identify LV myocardial abnormalities in uremic patients with preserved LVEF at early stage, as well as some changing regularities of LS and T-LS in the left ventricle. |
topic |
Speckle tracking echocardiography Ventricular function, left Strain Uremia Renal dialysis |
url |
http://link.springer.com/article/10.1186/s12938-018-0536-y |
work_keys_str_mv |
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