Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleading
This viewpoint article critiques two recent articles examining ‘willingness to risk death’ to advance HIV cure-related research. The ‘willingness to risk death’ endpoint sends the wrong signal to the HIV cure-related research community about ongoing research in otherwise healthy volunteers living wi...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-04-01
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Series: | Journal of Virus Eradication |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2055664020300212 |
Summary: | This viewpoint article critiques two recent articles examining ‘willingness to risk death’ to advance HIV cure-related research. The ‘willingness to risk death’ endpoint sends the wrong signal to the HIV cure-related research community about ongoing research in otherwise healthy volunteers living with HIV. Socio-behavioural scientists have examined the acceptability of a 99% risk of death scenario, which is unrealistic and would not be acceptable by current regulatory and ethical standards. We believe that the field needs robust and relevant socio-behavioural research reflecting ongoing biomedical HIV cure-related trials. These studies will need to withstand regulatory and ethical scrutiny if cure or remission regimens are to proceed to the licensing stage. The HIV cure-related research community must continue to protect the public trust in the HIV cure-related research field and sustain societal value generated by such research. We call for the utmost prudence in designing biomedical HIV cure trials as well as in setting up socio-behavioural research experiments related to these complex trials. |
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ISSN: | 2055-6640 |