Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleading
This viewpoint article critiques two recent articles examining ‘willingness to risk death’ to advance HIV cure-related research. The ‘willingness to risk death’ endpoint sends the wrong signal to the HIV cure-related research community about ongoing research in otherwise healthy volunteers living wi...
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doaj-46687b0064c2431e9ffcc65bf40873412021-05-05T04:04:07ZengElsevierJournal of Virus Eradication2055-66402020-04-01628184Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleadingKarine Dubé0Lynda Dee1Public Health Leadership Program, UNC Gillings School of Global Public Health, Chapel Hill, NC, USA; Corresponding author: Karine Dubé, UNC Gillings School of Global Public Health, 4108 McGavran-Greenberg Hall, Chapel Hill, NC27599, USADelaney AIDS Research Enterprise Community Advisory Board (CAB), Baltimore, MD, USA; amfAR Institute for HIV Cure Research CAB, Baltimore, MD, USA; AIDS Action Baltimore, MD, USAThis viewpoint article critiques two recent articles examining ‘willingness to risk death’ to advance HIV cure-related research. The ‘willingness to risk death’ endpoint sends the wrong signal to the HIV cure-related research community about ongoing research in otherwise healthy volunteers living with HIV. Socio-behavioural scientists have examined the acceptability of a 99% risk of death scenario, which is unrealistic and would not be acceptable by current regulatory and ethical standards. We believe that the field needs robust and relevant socio-behavioural research reflecting ongoing biomedical HIV cure-related trials. These studies will need to withstand regulatory and ethical scrutiny if cure or remission regimens are to proceed to the licensing stage. The HIV cure-related research community must continue to protect the public trust in the HIV cure-related research field and sustain societal value generated by such research. We call for the utmost prudence in designing biomedical HIV cure trials as well as in setting up socio-behavioural research experiments related to these complex trials.http://www.sciencedirect.com/science/article/pii/S2055664020300212risk of deathwillingness to participate (WTP)HIV cure-related researchotherwise healthy volunteerssocio-behavioural research |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karine Dubé Lynda Dee |
spellingShingle |
Karine Dubé Lynda Dee Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleading Journal of Virus Eradication risk of death willingness to participate (WTP) HIV cure-related research otherwise healthy volunteers socio-behavioural research |
author_facet |
Karine Dubé Lynda Dee |
author_sort |
Karine Dubé |
title |
Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleading |
title_short |
Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleading |
title_full |
Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleading |
title_fullStr |
Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleading |
title_full_unstemmed |
Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleading |
title_sort |
willingness to risk death endpoint in hiv cure-related research with otherwise healthy volunteers is misleading |
publisher |
Elsevier |
series |
Journal of Virus Eradication |
issn |
2055-6640 |
publishDate |
2020-04-01 |
description |
This viewpoint article critiques two recent articles examining ‘willingness to risk death’ to advance HIV cure-related research. The ‘willingness to risk death’ endpoint sends the wrong signal to the HIV cure-related research community about ongoing research in otherwise healthy volunteers living with HIV. Socio-behavioural scientists have examined the acceptability of a 99% risk of death scenario, which is unrealistic and would not be acceptable by current regulatory and ethical standards. We believe that the field needs robust and relevant socio-behavioural research reflecting ongoing biomedical HIV cure-related trials. These studies will need to withstand regulatory and ethical scrutiny if cure or remission regimens are to proceed to the licensing stage. The HIV cure-related research community must continue to protect the public trust in the HIV cure-related research field and sustain societal value generated by such research. We call for the utmost prudence in designing biomedical HIV cure trials as well as in setting up socio-behavioural research experiments related to these complex trials. |
topic |
risk of death willingness to participate (WTP) HIV cure-related research otherwise healthy volunteers socio-behavioural research |
url |
http://www.sciencedirect.com/science/article/pii/S2055664020300212 |
work_keys_str_mv |
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