Clue to the cause of portal hypertension: Look at the raindrops
Portal hypertension is a clinical syndrome characterized by splenomegaly, with or without hypersplenism, and esphagogastric varices. Non‐cirrhotic portal hypertension (NCPH) belongs to the presinusoidal sub category of portal hypertension. We present the case of a young 35‐year‐old male who had pres...
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doaj-467287c1c72849069f17a34436fb9c752021-05-02T15:36:14ZengWileyJGH Open2397-90702020-04-014229930010.1002/jgh3.12218Clue to the cause of portal hypertension: Look at the raindropsShubhra Mishra0Rahul Mahajan1Uma Saikia2Pankaj Gupta3Usha Dutta4Vishal Sharma5Harshal S Mandavdhare6Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh IndiaDepartment of Dermatology Postgraduate Institute of Medical Education and Research Chandigarh IndiaDepartment of Histopathology Postgraduate Institute of Medical Education and Research Chandigarh IndiaDepartment of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh IndiaDepartment of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh IndiaDepartment of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh IndiaDepartment of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh IndiaPortal hypertension is a clinical syndrome characterized by splenomegaly, with or without hypersplenism, and esphagogastric varices. Non‐cirrhotic portal hypertension (NCPH) belongs to the presinusoidal sub category of portal hypertension. We present the case of a young 35‐year‐old male who had presented with two episodes of upper gastrointestinal bleed. On endoscopy, he was found to have large esophageal varices. On general physical examination, there were diffuse hyperpigmented papules and nodules all over the body, with palmoplantar thickening. His liver function tests were normal. Computed tomography of the abdomen showed a dilated portal and splenic vein with splenomegaly and normal liver size and histopathology showed non‐cirrhotic portal fibrosis (NCPF). He had history of intake of oral indigenous medications for skin lesions. On investigating, patient was found to have chronic arsenicosis, which was likely the underlying etiology for NCPF as well. Hence, while evaluating patients of NCPF, it is imperative to rule out the use of indigenous medications, especially in the Indian scenario.https://doi.org/10.1002/jgh3.12218arsenic toxicityhepatologynon‐cirrhoticportal hypertensionraindrop appearance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shubhra Mishra Rahul Mahajan Uma Saikia Pankaj Gupta Usha Dutta Vishal Sharma Harshal S Mandavdhare |
spellingShingle |
Shubhra Mishra Rahul Mahajan Uma Saikia Pankaj Gupta Usha Dutta Vishal Sharma Harshal S Mandavdhare Clue to the cause of portal hypertension: Look at the raindrops JGH Open arsenic toxicity hepatology non‐cirrhotic portal hypertension raindrop appearance |
author_facet |
Shubhra Mishra Rahul Mahajan Uma Saikia Pankaj Gupta Usha Dutta Vishal Sharma Harshal S Mandavdhare |
author_sort |
Shubhra Mishra |
title |
Clue to the cause of portal hypertension: Look at the raindrops |
title_short |
Clue to the cause of portal hypertension: Look at the raindrops |
title_full |
Clue to the cause of portal hypertension: Look at the raindrops |
title_fullStr |
Clue to the cause of portal hypertension: Look at the raindrops |
title_full_unstemmed |
Clue to the cause of portal hypertension: Look at the raindrops |
title_sort |
clue to the cause of portal hypertension: look at the raindrops |
publisher |
Wiley |
series |
JGH Open |
issn |
2397-9070 |
publishDate |
2020-04-01 |
description |
Portal hypertension is a clinical syndrome characterized by splenomegaly, with or without hypersplenism, and esphagogastric varices. Non‐cirrhotic portal hypertension (NCPH) belongs to the presinusoidal sub category of portal hypertension. We present the case of a young 35‐year‐old male who had presented with two episodes of upper gastrointestinal bleed. On endoscopy, he was found to have large esophageal varices. On general physical examination, there were diffuse hyperpigmented papules and nodules all over the body, with palmoplantar thickening. His liver function tests were normal. Computed tomography of the abdomen showed a dilated portal and splenic vein with splenomegaly and normal liver size and histopathology showed non‐cirrhotic portal fibrosis (NCPF). He had history of intake of oral indigenous medications for skin lesions. On investigating, patient was found to have chronic arsenicosis, which was likely the underlying etiology for NCPF as well. Hence, while evaluating patients of NCPF, it is imperative to rule out the use of indigenous medications, especially in the Indian scenario. |
topic |
arsenic toxicity hepatology non‐cirrhotic portal hypertension raindrop appearance |
url |
https://doi.org/10.1002/jgh3.12218 |
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