Cerebrospinal Fluid Involvement in a Case of Visceral Leishmaniasis Associated with Hemophagocytic Lymphohistiocytosis
Hemophagocytic Lymphohistiocytosis (HLH) implies a benign generalized histiocytic proliferate with erythrophagocytosis and it includes familial hemophagocytic lymphohistiocytosis and secondary hemophgocytosis. Spinal fluid changes like mild to moderate pleocytosis (most of the cells are lymphocytes...
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Sultan Qaboos University
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doaj-4673d0d8b45d4d48915d86adf4cb6ed32020-11-25T02:43:12ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal 2075-051X2075-05282007-12-01732532561228Cerebrospinal Fluid Involvement in a Case of Visceral Leishmaniasis Associated with Hemophagocytic LymphohistiocytosisMahmoud Fathalla0Javad Hashim1Hussein Alkindy2Yasser Wali3Department of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University, P. O. Box 35, Al-Khod 123, Muscat, Sultanate of OmanDepartment of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University, P. O. Box 35, Al-Khod 123, Muscat, Sultanate of OmanDepartment of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University, P. O. Box 35, Al-Khod 123, Muscat, Sultanate of OmanDepartment of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University, P. O. Box 35, Al-Khod 123, Muscat, Sultanate of OmanHemophagocytic Lymphohistiocytosis (HLH) implies a benign generalized histiocytic proliferate with erythrophagocytosis and it includes familial hemophagocytic lymphohistiocytosis and secondary hemophgocytosis. Spinal fluid changes like mild to moderate pleocytosis (most of the cells are lymphocytes and macrophages) and sometimes hemophagocytosis are seen in primary HLH but are not reported in secondary HLH. Here we report a case of a previously healthy 10 months old male infant who was diagnosed as familial HLH with evidence of CSF hemophagocytosis. He was started on the HLH 2004 treatment protocol with no improvement. A second bone marrow aspiration revealed leshmania donovani antibodies and he was started on anti-leishmania treatment with dramatic response.To the best of our knowledge, this is the first case of secondary HLH with evidence of hemophagocytosis in cerebrospinal fluid.https://journals.squ.edu.om/index.php/squmj/article/view/1300lymphohistiocytosis, hemophagocyticleishmaniasiscerebrospinal fluidcase reportoman. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahmoud Fathalla Javad Hashim Hussein Alkindy Yasser Wali |
spellingShingle |
Mahmoud Fathalla Javad Hashim Hussein Alkindy Yasser Wali Cerebrospinal Fluid Involvement in a Case of Visceral Leishmaniasis Associated with Hemophagocytic Lymphohistiocytosis Sultan Qaboos University Medical Journal lymphohistiocytosis, hemophagocytic leishmaniasis cerebrospinal fluid case report oman. |
author_facet |
Mahmoud Fathalla Javad Hashim Hussein Alkindy Yasser Wali |
author_sort |
Mahmoud Fathalla |
title |
Cerebrospinal Fluid Involvement in a Case of Visceral Leishmaniasis Associated with Hemophagocytic Lymphohistiocytosis |
title_short |
Cerebrospinal Fluid Involvement in a Case of Visceral Leishmaniasis Associated with Hemophagocytic Lymphohistiocytosis |
title_full |
Cerebrospinal Fluid Involvement in a Case of Visceral Leishmaniasis Associated with Hemophagocytic Lymphohistiocytosis |
title_fullStr |
Cerebrospinal Fluid Involvement in a Case of Visceral Leishmaniasis Associated with Hemophagocytic Lymphohistiocytosis |
title_full_unstemmed |
Cerebrospinal Fluid Involvement in a Case of Visceral Leishmaniasis Associated with Hemophagocytic Lymphohistiocytosis |
title_sort |
cerebrospinal fluid involvement in a case of visceral leishmaniasis associated with hemophagocytic lymphohistiocytosis |
publisher |
Sultan Qaboos University |
series |
Sultan Qaboos University Medical Journal |
issn |
2075-051X 2075-0528 |
publishDate |
2007-12-01 |
description |
Hemophagocytic Lymphohistiocytosis (HLH) implies a benign generalized histiocytic proliferate with erythrophagocytosis and it includes familial hemophagocytic lymphohistiocytosis and secondary hemophgocytosis. Spinal fluid changes like mild to moderate pleocytosis (most of the cells are lymphocytes and macrophages) and sometimes hemophagocytosis are seen in primary HLH but are not reported in secondary HLH. Here we report a case of a previously healthy 10 months old male infant who was diagnosed as familial HLH with evidence of CSF hemophagocytosis. He was started on the HLH 2004 treatment protocol with no improvement. A second bone marrow aspiration revealed leshmania donovani antibodies and he was started on anti-leishmania treatment with dramatic response.To the best of our knowledge, this is the first case of secondary HLH with evidence of hemophagocytosis in cerebrospinal fluid. |
topic |
lymphohistiocytosis, hemophagocytic leishmaniasis cerebrospinal fluid case report oman. |
url |
https://journals.squ.edu.om/index.php/squmj/article/view/1300 |
work_keys_str_mv |
AT mahmoudfathalla cerebrospinalfluidinvolvementinacaseofvisceralleishmaniasisassociatedwithhemophagocyticlymphohistiocytosis AT javadhashim cerebrospinalfluidinvolvementinacaseofvisceralleishmaniasisassociatedwithhemophagocyticlymphohistiocytosis AT husseinalkindy cerebrospinalfluidinvolvementinacaseofvisceralleishmaniasisassociatedwithhemophagocyticlymphohistiocytosis AT yasserwali cerebrospinalfluidinvolvementinacaseofvisceralleishmaniasisassociatedwithhemophagocyticlymphohistiocytosis |
_version_ |
1724770836417609728 |