KANK2 Links αVβ5 Focal Adhesions to Microtubules and Regulates Sensitivity to Microtubule Poisons and Cell Migration

KANK2 Links αVβ5 Focal Adhesions to Microtubules and Regulates Sensitivity to Microtubule Poisons and Cell Migration

Integrins are heterodimeric glycoproteins that bind cells to extracellular matrix. Upon integrin clustering, multimolecular integrin adhesion complexes (IACs) are formed, creating links to the cell cytoskeleton. We have previously observed decreased cell migration and increased sensitivity to microt...

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Bibliographic Details
Main Authors: Mladen Paradžik, Jonathan D. Humphries, Nikolina Stojanović, Davor Nestić, Dragomira Majhen, Ana Dekanić, Ivana Samaržija, Delphine Sedda, Igor Weber, Martin J. Humphries, Andreja Ambriović-Ristov
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
adhesome
integrin αVβ5
antitumor drug resistance
cell migration
cortical microtubule stabilizing complex
KANK2
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00125/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00125/full

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