SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication.
Among the four non-structural proteins of alphaviruses the function of nsP3 is the least well understood. NsP3 is a component of the viral replication complex, and composed of a conserved aminoterminal macro domain implicated in viral RNA synthesis, and a poorly conserved carboxyterminal region. Des...
Main Authors: | Maarit Neuvonen, Arunas Kazlauskas, Miika Martikainen, Ari Hinkkanen, Tero Ahola, Kalle Saksela |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-11-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC3219718?pdf=render |
Similar Items
-
Interactions of Alphavirus nsP3 Protein with Host Proteins
by: Tyler Lark, et al.
Published: (2018-01-01) -
Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus
by: Margit Mutso, et al.
Published: (2018-04-01) -
The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last
by: Benjamin Götte, et al.
Published: (2018-02-01) -
Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice
by: Rachy Abraham, et al.
Published: (2020-02-01) -
Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication
by: Tim Schulte, et al.
Published: (2016-01-01)