A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria

A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria

A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901,...

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Main Authors: Wen-Li Mei, Zhen-Chang Wen, Yu-Juan Gan, Jiao Wu, Dong-Mei Que, Hao-Fu Dai
Format: Article
Language:English
Published: MDPI AG 2009-09-01
Series:Molecules
Subjects:
Antiaris toxicaria
toxicarioside H
nor-cardenolide
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/14/9/3694/
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spelling doaj-468b4b4aa241447d962455f755b91b642020-11-25T00:06:43ZengMDPI AGMolecules1420-30492009-09-011493694369910.3390/molecules14093694A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicariaWen-Li MeiZhen-Chang WenYu-Juan GanJiao WuDong-Mei QueHao-Fu DaiA new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method. http://www.mdpi.com/1420-3049/14/9/3694/Antiaris toxicariatoxicarioside Hnor-cardenolidecytotoxicity
collection DOAJ
language English
format Article
sources DOAJ
author Wen-Li Mei
Zhen-Chang Wen
Yu-Juan Gan
Jiao Wu
Dong-Mei Que
Hao-Fu Dai
spellingShingle Wen-Li Mei
Zhen-Chang Wen
Yu-Juan Gan
Jiao Wu
Dong-Mei Que
Hao-Fu Dai
A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
Molecules
Antiaris toxicaria
toxicarioside H
nor-cardenolide
cytotoxicity
author_facet Wen-Li Mei
Zhen-Chang Wen
Yu-Juan Gan
Jiao Wu
Dong-Mei Que
Hao-Fu Dai
author_sort Wen-Li Mei
title A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
title_short A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
title_full A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
title_fullStr A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
title_full_unstemmed A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria
title_sort new cytotoxic 19-nor-cardenolide from the latex of antiaris toxicaria
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2009-09-01
description A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.
topic Antiaris toxicaria
toxicarioside H
nor-cardenolide
cytotoxicity
url http://www.mdpi.com/1420-3049/14/9/3694/
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