Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity

Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity

Dominantly inherited mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common causes of familial Parkinson's disease (PD) and LRRK2 polymorphisms are associated with increased risk for idiopathic PD. However, the molecular mechanisms by which these mutations cause PD remain uncerta...

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Bibliographic Details
Main Authors: Xiaodong Ding, Sandeep K. Barodia, Lisha Ma, Matthew S. Goldberg
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Neurobiology of Disease
Subjects:
LRRK2
Kinase
Cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302637

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