A molecular theory of germinal center B cell selection and division
Summary: The selection of B cells (BCs) in germinal centers (GCs) is pivotal to the generation of high-affinity antibodies and memory BCs, but it lacks global understanding. Based on the idea of a single Tfh-cell signal that controls BC selection and division, experiments appear contradictory. Here,...
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doaj-469bd26b71974c9d918ecf485d0bf8752021-08-26T04:33:11ZengElsevierCell Reports2211-12472021-08-01368109552A molecular theory of germinal center B cell selection and divisionMichael Meyer-Hermann0Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, Rebenring 56, Braunschweig 38106, Germany; Centre for Individualised Infection Medicine (CIIM), Hannover, Germany; Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany; Corresponding authorSummary: The selection of B cells (BCs) in germinal centers (GCs) is pivotal to the generation of high-affinity antibodies and memory BCs, but it lacks global understanding. Based on the idea of a single Tfh-cell signal that controls BC selection and division, experiments appear contradictory. Here, we use the current knowledge on the molecular pathways of GC BCs to develop a theory of GC BC selection and division based on the dynamics of molecular factors. This theory explains the seemingly contradictory experiments by the separation of signals for BC fate decision from signals controlling the number of BC divisions. Three model variants are proposed and experiments are predicted that allow one to distinguish those. Understanding information processing in molecular BC states is critical for targeted immune interventions, and the proposed theory implies that selection and division can be controlled independently in GC reactions.http://www.sciencedirect.com/science/article/pii/S2211124721009864germinal centeraffinity maturationmathematical modelB cell selectionB cell divisionB cell signaling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael Meyer-Hermann |
spellingShingle |
Michael Meyer-Hermann A molecular theory of germinal center B cell selection and division Cell Reports germinal center affinity maturation mathematical model B cell selection B cell division B cell signaling |
author_facet |
Michael Meyer-Hermann |
author_sort |
Michael Meyer-Hermann |
title |
A molecular theory of germinal center B cell selection and division |
title_short |
A molecular theory of germinal center B cell selection and division |
title_full |
A molecular theory of germinal center B cell selection and division |
title_fullStr |
A molecular theory of germinal center B cell selection and division |
title_full_unstemmed |
A molecular theory of germinal center B cell selection and division |
title_sort |
molecular theory of germinal center b cell selection and division |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2021-08-01 |
description |
Summary: The selection of B cells (BCs) in germinal centers (GCs) is pivotal to the generation of high-affinity antibodies and memory BCs, but it lacks global understanding. Based on the idea of a single Tfh-cell signal that controls BC selection and division, experiments appear contradictory. Here, we use the current knowledge on the molecular pathways of GC BCs to develop a theory of GC BC selection and division based on the dynamics of molecular factors. This theory explains the seemingly contradictory experiments by the separation of signals for BC fate decision from signals controlling the number of BC divisions. Three model variants are proposed and experiments are predicted that allow one to distinguish those. Understanding information processing in molecular BC states is critical for targeted immune interventions, and the proposed theory implies that selection and division can be controlled independently in GC reactions. |
topic |
germinal center affinity maturation mathematical model B cell selection B cell division B cell signaling |
url |
http://www.sciencedirect.com/science/article/pii/S2211124721009864 |
work_keys_str_mv |
AT michaelmeyerhermann amoleculartheoryofgerminalcenterbcellselectionanddivision AT michaelmeyerhermann moleculartheoryofgerminalcenterbcellselectionanddivision |
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1721196196850040832 |