Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine
BackgroundSelenium (Se) is a nutritionally essential trace element and health may be improved by increased Se intake. Previous kinetic studies have shown differences in metabolism of organic vs. inorganic forms of Se [e.g., higher absorption of selenomethionine (SeMet) than selenite (Sel), and more...
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Frontiers Media S.A.
2021-03-01
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doaj-46b0a59f7d6942699ebdb5dbc40b694c2021-03-30T14:11:10ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-03-011210.3389/fendo.2021.621687621687Selenium Kinetics in Humans Change Following 2 Years of Supplementation With SelenomethionineBlossom H. Patterson0Gerald F. Combs1Philip R. Taylor2Kristine Y. Patterson3James E. Moler4Meryl E. Wastney5Biometry Research Group, Division of Cancer Prevention (DCP), National Cancer Institute, Bethesda, MD, United StatesDivision of Nutritional Sciences, Cornell University, Ithaca, NY, United StatesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United StatesBeltsville Human Nutrition Research Center, United States Department of Agriculture-Agricultural Research Service (USDA-ARS), Beltsville, MD, United StatesInformation Management Services, Inc., Rockville, MD, United StatesMetabolic Modeling Services, West Lafayette, IN, United StatesBackgroundSelenium (Se) is a nutritionally essential trace element and health may be improved by increased Se intake. Previous kinetic studies have shown differences in metabolism of organic vs. inorganic forms of Se [e.g., higher absorption of selenomethionine (SeMet) than selenite (Sel), and more recycling of Se from SeMet than Sel]. However, the effects on Se metabolism after prolonged Se supplementation are not known.ObjectiveTo determine how the metabolism and transport of Se changes in the whole-body in response to Se-supplementation by measuring Se kinetics before and after 2 years of Se supplementation with SeMet.MethodsWe compared Se kinetics in humans [n = 31, aged 40 ± 3 y (mean ± SEM)] studied twice after oral tracer administration; initially (PK1), then after supplementation for 2 y with 200 µg/d of Se as selenomethionine (SeMet) (PK2). On each occasion, we administered two stable isotope tracers of Se orally: SeMet, the predominant food form, and selenite (Na276SeO3, or Sel), an inorganic form. Plasma and RBC were sampled for 4 mo; urine and feces were collected for the initial 12 d of each period. Samples were analyzed for tracers and total Se by isotope dilution GC-MS. Data were analyzed using a compartmental model, we published previously, to estimate fractional transfer between pools and pool masses in PK2.ResultsWe report that fractional absorption of SeMet or Sel do not change with SeMet supplementation and the amount of Se absorbed increased. The amount of Se excreted in urine increases but does not account for all the Se absorbed. As a result, there is a net incorporation of SeMet into various body pools. Nine of the 11 plasma pools doubled in PK2; two did not change. Differences in metabolism were observed for SeMet and Sel; RBC uptake increased 247% for SeMet, urinary excretion increased from two plasma pools for Sel and from two different pools for SeMet, and recycling to liver/tissues increased from one plasma pool for Sel and from two others for SeMet. One plasma pool increased more in males than females in PK2.ConclusionsOf 11 Se pools identified kinetically in human plasma, two did not increase in size after SeMet supplementation. These pools may be regulated and important during low Se intake.https://www.frontiersin.org/articles/10.3389/fendo.2021.621687/fullseleniummetabolismtrace elementsseleniteselenomethioninekinetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Blossom H. Patterson Gerald F. Combs Philip R. Taylor Kristine Y. Patterson James E. Moler Meryl E. Wastney |
spellingShingle |
Blossom H. Patterson Gerald F. Combs Philip R. Taylor Kristine Y. Patterson James E. Moler Meryl E. Wastney Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine Frontiers in Endocrinology selenium metabolism trace elements selenite selenomethionine kinetics |
author_facet |
Blossom H. Patterson Gerald F. Combs Philip R. Taylor Kristine Y. Patterson James E. Moler Meryl E. Wastney |
author_sort |
Blossom H. Patterson |
title |
Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine |
title_short |
Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine |
title_full |
Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine |
title_fullStr |
Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine |
title_full_unstemmed |
Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine |
title_sort |
selenium kinetics in humans change following 2 years of supplementation with selenomethionine |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2021-03-01 |
description |
BackgroundSelenium (Se) is a nutritionally essential trace element and health may be improved by increased Se intake. Previous kinetic studies have shown differences in metabolism of organic vs. inorganic forms of Se [e.g., higher absorption of selenomethionine (SeMet) than selenite (Sel), and more recycling of Se from SeMet than Sel]. However, the effects on Se metabolism after prolonged Se supplementation are not known.ObjectiveTo determine how the metabolism and transport of Se changes in the whole-body in response to Se-supplementation by measuring Se kinetics before and after 2 years of Se supplementation with SeMet.MethodsWe compared Se kinetics in humans [n = 31, aged 40 ± 3 y (mean ± SEM)] studied twice after oral tracer administration; initially (PK1), then after supplementation for 2 y with 200 µg/d of Se as selenomethionine (SeMet) (PK2). On each occasion, we administered two stable isotope tracers of Se orally: SeMet, the predominant food form, and selenite (Na276SeO3, or Sel), an inorganic form. Plasma and RBC were sampled for 4 mo; urine and feces were collected for the initial 12 d of each period. Samples were analyzed for tracers and total Se by isotope dilution GC-MS. Data were analyzed using a compartmental model, we published previously, to estimate fractional transfer between pools and pool masses in PK2.ResultsWe report that fractional absorption of SeMet or Sel do not change with SeMet supplementation and the amount of Se absorbed increased. The amount of Se excreted in urine increases but does not account for all the Se absorbed. As a result, there is a net incorporation of SeMet into various body pools. Nine of the 11 plasma pools doubled in PK2; two did not change. Differences in metabolism were observed for SeMet and Sel; RBC uptake increased 247% for SeMet, urinary excretion increased from two plasma pools for Sel and from two different pools for SeMet, and recycling to liver/tissues increased from one plasma pool for Sel and from two others for SeMet. One plasma pool increased more in males than females in PK2.ConclusionsOf 11 Se pools identified kinetically in human plasma, two did not increase in size after SeMet supplementation. These pools may be regulated and important during low Se intake. |
topic |
selenium metabolism trace elements selenite selenomethionine kinetics |
url |
https://www.frontiersin.org/articles/10.3389/fendo.2021.621687/full |
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