2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls

2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls

Abstract Background Chronic obstructive pulmonary disease (COPD) is associated with several extra-pulmonary effects of which skeletal muscle wasting is one of the most common and contributes to reduced quality of life, increased morbidity and mortality. The molecular mechanisms leading to muscle was...

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Bibliographic Details
Main Authors: Ramzi Lakhdar, Ellen M. Drost, William MacNee, Ricardo Bastos, Roberto A. Rabinovich
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Respiratory Research
Subjects:
COPD
Skeletal muscle dysfunction/wasting
Proteomic analysis
2D-DIGE
DOT1L
Ageing
Online Access:http://link.springer.com/article/10.1186/s12931-017-0525-x

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