Origins of the Vertebrate Erythro/Megakaryocytic System
Vertebrate erythrocytes and thrombocytes arise from the common bipotent thrombocytic-erythroid progenitors (TEPs). Even though nonmammalian erythrocytes and thrombocytes are phenotypically very similar to each other, mammalian species have developed some key evolutionary improvements in the process...
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Online Access: | http://dx.doi.org/10.1155/2015/632171 |
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doaj-46be2c6528754b05a7d288b96e1257ac2020-11-25T01:10:31ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/632171632171Origins of the Vertebrate Erythro/Megakaryocytic SystemOndrej Svoboda0Petr Bartunek1Department of Cell Differentiation, Institute of Molecular Genetics AS CR v.v.i., 142 20 Prague 4, Czech RepublicDepartment of Cell Differentiation, Institute of Molecular Genetics AS CR v.v.i., 142 20 Prague 4, Czech RepublicVertebrate erythrocytes and thrombocytes arise from the common bipotent thrombocytic-erythroid progenitors (TEPs). Even though nonmammalian erythrocytes and thrombocytes are phenotypically very similar to each other, mammalian species have developed some key evolutionary improvements in the process of erythroid and thrombocytic differentiation, such as erythroid enucleation, megakaryocyte endoreduplication, and platelet formation. This brings up a few questions that we try to address in this review. Specifically, we describe the ontology of erythro-thrombopoiesis during adult hematopoiesis with focus on the phylogenetic origin of mammalian erythrocytes and thrombocytes (also termed platelets). Although the evolutionary relationship between mammalian and nonmammalian erythroid cells is clear, the appearance of mammalian megakaryocytes is less so. Here, we discuss recent data indicating that nonmammalian thrombocytes and megakaryocytes are homologs. Finally, we hypothesize that erythroid and thrombocytic differentiation evolved from a single ancestral lineage, which would explain the striking similarities between these cells.http://dx.doi.org/10.1155/2015/632171 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ondrej Svoboda Petr Bartunek |
spellingShingle |
Ondrej Svoboda Petr Bartunek Origins of the Vertebrate Erythro/Megakaryocytic System BioMed Research International |
author_facet |
Ondrej Svoboda Petr Bartunek |
author_sort |
Ondrej Svoboda |
title |
Origins of the Vertebrate Erythro/Megakaryocytic System |
title_short |
Origins of the Vertebrate Erythro/Megakaryocytic System |
title_full |
Origins of the Vertebrate Erythro/Megakaryocytic System |
title_fullStr |
Origins of the Vertebrate Erythro/Megakaryocytic System |
title_full_unstemmed |
Origins of the Vertebrate Erythro/Megakaryocytic System |
title_sort |
origins of the vertebrate erythro/megakaryocytic system |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Vertebrate erythrocytes and thrombocytes arise from the common bipotent thrombocytic-erythroid progenitors (TEPs). Even though nonmammalian erythrocytes and thrombocytes are phenotypically very similar to each other, mammalian species have developed some key evolutionary improvements in the process of erythroid and thrombocytic differentiation, such as erythroid enucleation, megakaryocyte endoreduplication, and platelet formation. This brings up a few questions that we try to address in this review. Specifically, we describe the ontology of erythro-thrombopoiesis during adult hematopoiesis with focus on the phylogenetic origin of mammalian erythrocytes and thrombocytes (also termed platelets). Although the evolutionary relationship between mammalian and nonmammalian erythroid cells is clear, the appearance of mammalian megakaryocytes is less so. Here, we discuss recent data indicating that nonmammalian thrombocytes and megakaryocytes are homologs. Finally, we hypothesize that erythroid and thrombocytic differentiation evolved from a single ancestral lineage, which would explain the striking similarities between these cells. |
url |
http://dx.doi.org/10.1155/2015/632171 |
work_keys_str_mv |
AT ondrejsvoboda originsofthevertebrateerythromegakaryocyticsystem AT petrbartunek originsofthevertebrateerythromegakaryocyticsystem |
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