The Mckittrick-Wheelock Syndrome: A Rare Cause of Severe Hydroelectrolyte Disorders and Acute Renal Failure

The Mckittrick-Wheelock Syndrome: A Rare Cause of Severe Hydroelectrolyte Disorders and Acute Renal Failure

The McKittrick-Wheelock syndrome is a rare cause of severe hydroelectrolyte disorders and fluid depletion as a result of rectal tumor hypersecretion, which can lead to acute renal failure. We report the case of a 70-year-old female who presented with hyponatremia, hypokalemia, hypochloremia, and acu...

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Main Authors: Andrea Bruno, Domenico Chimienti, Alda Montanaro, Fernando Prete, Pasquale Libutti, Piero Lisi, Carlo Basile
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Case Reports in Nephrology
Online Access:http://dx.doi.org/10.1155/2011/765689
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spelling doaj-46caaa879e124c16b865eccd4c1b9bbc2020-11-24T22:51:10ZengHindawi LimitedCase Reports in Nephrology2090-66412090-665X2011-01-01201110.1155/2011/765689765689The Mckittrick-Wheelock Syndrome: A Rare Cause of Severe Hydroelectrolyte Disorders and Acute Renal FailureAndrea Bruno0Domenico Chimienti1Alda Montanaro2Fernando Prete3Pasquale Libutti4Piero Lisi5Carlo Basile6Division of Nephrology, Miulli General Hospital, 70021 Acquaviva delle Fonti, ItalyDivision of Nephrology, Miulli General Hospital, 70021 Acquaviva delle Fonti, ItalyDivision of Surgery, Miulli General Hospital, 70021 Acquaviva delle Fonti, ItalyDivision of Surgery, Miulli General Hospital, 70021 Acquaviva delle Fonti, ItalyDivision of Nephrology, Miulli General Hospital, 70021 Acquaviva delle Fonti, ItalyDivision of Nephrology, Miulli General Hospital, 70021 Acquaviva delle Fonti, ItalyDivision of Nephrology, Miulli General Hospital, 70021 Acquaviva delle Fonti, ItalyThe McKittrick-Wheelock syndrome is a rare cause of severe hydroelectrolyte disorders and fluid depletion as a result of rectal tumor hypersecretion, which can lead to acute renal failure. We report the case of a 70-year-old female who presented with hyponatremia, hypokalemia, hypochloremia, and acute renal failure, due to a watery, mucinous diarrhea. A large rectal villous adenoma was discovered on ileocolonoscopy, and definitive management was achieved by removal of the tumor. In conclusion, reversal of the biochemical derangement is the cornerstone of successful management of the McKittrick-Wheelock syndrome. Then, immediate surgical resection of the tumor is the treatment of choice.http://dx.doi.org/10.1155/2011/765689
collection DOAJ
language English
format Article
sources DOAJ
author Andrea Bruno
Domenico Chimienti
Alda Montanaro
Fernando Prete
Pasquale Libutti
Piero Lisi
Carlo Basile
spellingShingle Andrea Bruno
Domenico Chimienti
Alda Montanaro
Fernando Prete
Pasquale Libutti
Piero Lisi
Carlo Basile
The Mckittrick-Wheelock Syndrome: A Rare Cause of Severe Hydroelectrolyte Disorders and Acute Renal Failure
Case Reports in Nephrology
author_facet Andrea Bruno
Domenico Chimienti
Alda Montanaro
Fernando Prete
Pasquale Libutti
Piero Lisi
Carlo Basile
author_sort Andrea Bruno
title The Mckittrick-Wheelock Syndrome: A Rare Cause of Severe Hydroelectrolyte Disorders and Acute Renal Failure
title_short The Mckittrick-Wheelock Syndrome: A Rare Cause of Severe Hydroelectrolyte Disorders and Acute Renal Failure
title_full The Mckittrick-Wheelock Syndrome: A Rare Cause of Severe Hydroelectrolyte Disorders and Acute Renal Failure
title_fullStr The Mckittrick-Wheelock Syndrome: A Rare Cause of Severe Hydroelectrolyte Disorders and Acute Renal Failure
title_full_unstemmed The Mckittrick-Wheelock Syndrome: A Rare Cause of Severe Hydroelectrolyte Disorders and Acute Renal Failure
title_sort mckittrick-wheelock syndrome: a rare cause of severe hydroelectrolyte disorders and acute renal failure
publisher Hindawi Limited
series Case Reports in Nephrology
issn 2090-6641
2090-665X
publishDate 2011-01-01
description The McKittrick-Wheelock syndrome is a rare cause of severe hydroelectrolyte disorders and fluid depletion as a result of rectal tumor hypersecretion, which can lead to acute renal failure. We report the case of a 70-year-old female who presented with hyponatremia, hypokalemia, hypochloremia, and acute renal failure, due to a watery, mucinous diarrhea. A large rectal villous adenoma was discovered on ileocolonoscopy, and definitive management was achieved by removal of the tumor. In conclusion, reversal of the biochemical derangement is the cornerstone of successful management of the McKittrick-Wheelock syndrome. Then, immediate surgical resection of the tumor is the treatment of choice.
url http://dx.doi.org/10.1155/2011/765689
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