Infection by Streptococcus pneumoniae in children with or without radiologically confirmed pneumonia
Abstract Objective: Community-acquired pneumonia is an important cause of morbidity in childhood, but the detection of its causative agent remains a diagnostic challenge. The authors aimed to evaluate the role of the chest radiograph to identify cases of community-aquired pneumonia caused by typica...
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doaj-46cd2b738420485f9f2ba66af222896d2020-11-24T23:03:30ZengElsevierJornal de Pediatria1678-4782941233010.1016/j.jped.2017.03.004S0021-75572018000100023Infection by Streptococcus pneumoniae in children with or without radiologically confirmed pneumoniaDafne C. AndradeIgor C. BorgesAna Luísa Vilas-BoasMaria S.H. FontouraCésar A. Araújo-NetoSandra C. AndradeRosa V. BrimAndreas MeinkeAldina BarralOlli RuuskanenHelena KäyhtyCristiana M. Nascimento-CarvalhoAbstract Objective: Community-acquired pneumonia is an important cause of morbidity in childhood, but the detection of its causative agent remains a diagnostic challenge. The authors aimed to evaluate the role of the chest radiograph to identify cases of community-aquired pneumonia caused by typical bacteria. Methods: The frequency of infection by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis was compared in non-hospitalized children with clinical diagnosis of community acquired pneumonia aged 2-59 months with or without radiological confirmation (n = 249 and 366, respectively). Infection by S. pneumoniae was diagnosed by the detection of a serological response against at least one of eight pneumococcal proteins (defined as an increase ≥2-fold in the IgG levels against Ply, CbpA, PspA1 and PspA2, PhtD, StkP-C, and PcsB-N, or an increase ≥1.5-fold against PcpA). Infection by H. influenzae and M. catarrhalis was defined as an increase ≥2-fold on the levels of microbe-specific IgG. Results: Children with radiologically confirmed pneumonia had higher rates of infection by S. pneumoniae. The presence of pneumococcal infection increased the odds of having radiologically confirmed pneumonia by 2.8 times (95% CI: 1.8-4.3). The negative predictive value of the normal chest radiograph for infection by S. pneumoniae was 86.3% (95% CI: 82.4-89.7%). There was no difference on the rates of infection by H. influenzae and M. catarrhalis between children with community-acquired pneumonia with and without radiological confirmation. Conclusions: Among children with clinical diagnosis of community-acquired pneumonia submitted to chest radiograph, those with radiologically confirmed pneumonia present a higher rate of infection by S. pneumoniae when compared with those with a normal chest radiograph.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572018000100023&lng=en&tlng=enInfecção bacterianaEtiologiaInfecção do trato respiratório inferiorEstudo radiológicoTestes sorológicos |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dafne C. Andrade Igor C. Borges Ana Luísa Vilas-Boas Maria S.H. Fontoura César A. Araújo-Neto Sandra C. Andrade Rosa V. Brim Andreas Meinke Aldina Barral Olli Ruuskanen Helena Käyhty Cristiana M. Nascimento-Carvalho |
spellingShingle |
Dafne C. Andrade Igor C. Borges Ana Luísa Vilas-Boas Maria S.H. Fontoura César A. Araújo-Neto Sandra C. Andrade Rosa V. Brim Andreas Meinke Aldina Barral Olli Ruuskanen Helena Käyhty Cristiana M. Nascimento-Carvalho Infection by Streptococcus pneumoniae in children with or without radiologically confirmed pneumonia Jornal de Pediatria Infecção bacteriana Etiologia Infecção do trato respiratório inferior Estudo radiológico Testes sorológicos |
author_facet |
Dafne C. Andrade Igor C. Borges Ana Luísa Vilas-Boas Maria S.H. Fontoura César A. Araújo-Neto Sandra C. Andrade Rosa V. Brim Andreas Meinke Aldina Barral Olli Ruuskanen Helena Käyhty Cristiana M. Nascimento-Carvalho |
author_sort |
Dafne C. Andrade |
title |
Infection by Streptococcus pneumoniae in children with or without radiologically confirmed pneumonia |
title_short |
Infection by Streptococcus pneumoniae in children with or without radiologically confirmed pneumonia |
title_full |
Infection by Streptococcus pneumoniae in children with or without radiologically confirmed pneumonia |
title_fullStr |
Infection by Streptococcus pneumoniae in children with or without radiologically confirmed pneumonia |
title_full_unstemmed |
Infection by Streptococcus pneumoniae in children with or without radiologically confirmed pneumonia |
title_sort |
infection by streptococcus pneumoniae in children with or without radiologically confirmed pneumonia |
publisher |
Elsevier |
series |
Jornal de Pediatria |
issn |
1678-4782 |
description |
Abstract Objective: Community-acquired pneumonia is an important cause of morbidity in childhood, but the detection of its causative agent remains a diagnostic challenge. The authors aimed to evaluate the role of the chest radiograph to identify cases of community-aquired pneumonia caused by typical bacteria. Methods: The frequency of infection by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis was compared in non-hospitalized children with clinical diagnosis of community acquired pneumonia aged 2-59 months with or without radiological confirmation (n = 249 and 366, respectively). Infection by S. pneumoniae was diagnosed by the detection of a serological response against at least one of eight pneumococcal proteins (defined as an increase ≥2-fold in the IgG levels against Ply, CbpA, PspA1 and PspA2, PhtD, StkP-C, and PcsB-N, or an increase ≥1.5-fold against PcpA). Infection by H. influenzae and M. catarrhalis was defined as an increase ≥2-fold on the levels of microbe-specific IgG. Results: Children with radiologically confirmed pneumonia had higher rates of infection by S. pneumoniae. The presence of pneumococcal infection increased the odds of having radiologically confirmed pneumonia by 2.8 times (95% CI: 1.8-4.3). The negative predictive value of the normal chest radiograph for infection by S. pneumoniae was 86.3% (95% CI: 82.4-89.7%). There was no difference on the rates of infection by H. influenzae and M. catarrhalis between children with community-acquired pneumonia with and without radiological confirmation. Conclusions: Among children with clinical diagnosis of community-acquired pneumonia submitted to chest radiograph, those with radiologically confirmed pneumonia present a higher rate of infection by S. pneumoniae when compared with those with a normal chest radiograph. |
topic |
Infecção bacteriana Etiologia Infecção do trato respiratório inferior Estudo radiológico Testes sorológicos |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572018000100023&lng=en&tlng=en |
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